Coffee consumption and risk of lung cancer: A meta-analysis
ABSTRACT Epidemiologic studies have evaluated the potential association between coffee consumption and lung cancer risk. However, results were inconsistent. To clarify the role of coffee in lung cancer, we conducted a meta-analysis on this topic. We searched PubMed and EMBASE databases (from 1966 to January 2009) and the reference lists of retrieved articles. Study-specific risk estimates were pooled using random-effects model. Five prospective studies and 8 case-control studies involving 5347 lung cancer cases and 104,911 non-cases were included in this meta-analysis. The combined results indicated a significant positive association between highest coffee intake and lung cancer [relative risk (RR)=1.27, 95% confidence interval (CI)=1.04-1.54). Furthermore, an increase in coffee consumption of 2 cups/day was associated with a 14% increased risk of developing lung cancer (RR=1.14, 95% CI=1.04-1.26). In stratified analyses, the highest coffee consumption was significantly associated with increased risk of lung cancer in prospective studies, studies conducted in America and Japan, but borderline significantly associated with decreased risk of lung cancer in non-smokers. In addition, decaffeinated coffee drinking was associated with decreased lung cancer risk, although the number of studies on this topic was relative small. In conclusion, results from this meta-analysis indicate that high or an increased consumption of coffee may increase the risk of lung cancer. Because the residual confounding effects of smoking or other factors may still exist, these results should be interpreted with caution.
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ABSTRACT: Coffee is one of the most widely consumed beverages and a major dietary exposure in the world. In 2007, the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) concluded in its report that for the association between lung cancer with dietary exposures such as coffee intake, the data were either of too low quality, or too inconsistent or the number of studies were too few to allow conclusions to be reached . A meta-analysis (2010) of 13 studies reported significant positive association between coffee consumption and lung cancer risk . However, there may still be residual confounding due to smoking.We sought to examine the association between coffee consumption and lung cancer risk in a large French population-based case–control study, the ICARE study (Investigation of occupational and environmental causes of respiratory cancers). The large sample size of this study allowed us to assess the association by gender, smoking status and histological ty ...European Journal of Epidemiology 12/2014; 30(1). DOI:10.1007/s10654-014-9976-2 · 5.15 Impact Factor
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ABSTRACT: Tea and coffee are the most commonly consumed beverages in the worldwide. The relationship between tea and coffee consumption on the risk of laryngeal cancer was still unclear. Relevant studies were identified by searching electronic database (Medline and EMBASE) and reviewing the reference lists of relevant articles until Oct. 2013. Observational studies that reported RRs and 95% CIs for the link of tea and coffee consumption on the risk of laryngeal cancer were eligible. A meta-analysis was obtained to combine study-specific RRs with a random-effects model. A total of 2,803 cases and 503,234 controls in 10 independent studies were identified. The overall analysis of all 10 studies, including the case-control and cohort studies, found that tea drinking was not associated with laryngeal carcinoma (RR = 1.03; 95% CI: 0.66-1.61). However, coffee consumption was significantly associated with the laryngeal carcinoma (RR = 1.47; 95% CI: 1.03-2.11). A dose-response relationship between coffee intake and laryngeal carcinoma was detected; however, no evidence of dose-response link between tea consumption and laryngeal carcinoma risk was detected. The results from this meta-analysis of observational studies demonstrate that coffee consumption would increase the laryngeal cancer risk, while tea intake was not associated with risk of laryngeal carcinoma.PLoS ONE 12/2014; 9(12):e112006. DOI:10.1371/journal.pone.0112006 · 3.53 Impact Factor