Article

Testosterone and dehydroepiandrosterone sulphate levels and IVF/ICSI results.

Vali-e-Asr Reproductive Health Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
Gynecological Endocrinology (impact factor: 1.58). 03/2009; 25(3):194-8. DOI:10.1080/09513590802582644 pp.194-8
Source: PubMed

ABSTRACT To determine the effect of serum androgens [testosterone and dehydroepiandrosterone sulphate (DHEAS)] on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes.
This observational (cross sectional) study was conducted on 53 consecutive infertile women undergoing IVF cycles in an academic infertility clinic between September 2006 and August 2007. Basal testosterone and DHEAS were measured and on third day of IVF cycle and on 14th day of embryo transfer these values were re-checked. Serum beta-hCG analysis was done 12 days after embryo transfer and ultrasound scan was scheduled 2 weeks later.
Testosterone level was significantly elevated in pregnant women on 14th day of embryo transfer (p < 0.001). Testosterone and DHEAS concentrations on third day of IVF cycle and DHEAS concentration 2 weeks after embryo transfer had not significant correlation with IVF success, but mean androgens concentrations were higher in pregnant group.
Serum testosterone concentration on 14th day of embryo transfer can predict successful IVF cycles, so with regulating androgen levels, improved pregnancy rates can be expected.

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    Article: Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR).
    Norbert Gleicher, David H Barad
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    ABSTRACT: With infertility populations in the developed world rapidly aging, treatment of diminished ovarian reserve (DOR) assumes increasing clinical importance. Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances with DOR, and is now utilized by approximately one third of all IVF centers world-wide. Increasing DHEA utilization and publication of a first prospectively randomized trial now warrants a systematic review. PubMed, Cochrane and Ovid Medline were searched between 1995 and 2010 under the following strategy: [ and ]. Bibliographies of relevant publications were further explored for additional relevant citations. Since only one randomized study has been published, publications, independent of evidence levels and quality assessment, were reviewed. Current best available evidence suggests that DHEA improves ovarian function, increases pregnancy chances and, by reducing aneuploidy, lowers miscarriage rates. DHEA over time also appears to objectively improve ovarian reserve. Recent animal data support androgens in promoting preantral follicle growth and reduction in follicle atresia. Improvement of oocyte/embryo quality with DHEA supplementation potentially suggests a new concept of ovarian aging, where ovarian environments, but not oocytes themselves, age. DHEA may, thus, represent a first agent beneficially affecting aging ovarian environments. Others can be expected to follow.
    Reproductive Biology and Endocrinology 01/2011; 9:67. · 2.05 Impact Factor
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Keywords

53 consecutive infertile women undergoing IVF cycles
 
academic infertility clinic
 
androgens concentrations
 
Basal testosterone
 
dehydroepiandrosterone sulphate
 
DHEAS concentration 2 weeks
 
DHEAS concentrations
 
embryo transfer
 
IVF success
 
pregnant group
 
regulating androgen levels
 
serum androgens [testosterone
 
Serum beta-hCG analysis
 
Serum testosterone concentration
 
successful IVF cycles
 
Testosterone level
 
third day
 
ultrasound scan
 
values
 
vitro fertilization/intracytoplasmic sperm injection
 

Batool Rashidi