Article

Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis.

Laboratory of Clinical and Experimental Pathology, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002 Nice, France.
Pathology - Research and Practice (Impact Factor: 1.21). 05/2009; 206(1):66-72. DOI: 10.1016/j.prp.2009.02.008
Source: PubMed

ABSTRACT Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes. We report a case of oncocytic lipoadenoma showing sebaceous differentiation, and provide a cytogenetic analysis, which has not yet been described. A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components. Immunohistochemistry showed a dual epithelial population with ductal (positivity for AE1/AE3, CK19, CK7 antibodies) and basal-cell (positivity for p63, CK14, CK5,6 antibodies) differentiation in oncocytic areas. Moreover, oncocytic cells were stained with anti-alpha-1 antichymotrypsin antibody and phosphotungstic acid-hematoxylin staining. Molecular cytogenetic analysis showed a translocation t(12;14), resulting in structural rearrangement of the region framing the HMGA2 gene at 12q14.3. Such alterations in HMGA2 have been described in both lipomas and pleomorphic adenomas of the salivary glands.

0 Bookmarks
 · 
204 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Sialolipoma, a rare tumor of the salivary gland, is a recently described variant of salivary gland lipoma. Oncocytic sialolipoma was first described by Pusiol et al. in 2009. We report the case of an oncocytic sialolipoma of the submandibular gland in a 43-year-old female. Excision of the tumor was performed with preservation of the submandibular gland. The tumor had a thin, fibrous capsule and consisted of abundant adipose tissue, an oncocytic nodule, and scattered normal glandular structures surrounded by adipose tissue. Four cases of sialolipoma of the submandibular gland, including the present case, were reviewed. All 4 tumors were developed on the right submandibular glands, with a composition of adipose tissue as high as that of sialolipoma of the parotid gland; in contrast to previous reports, three cases were in females. As newly described tumor type, care should be taken to distinguish oncocytic sialolipoma from other salivary gland neoplasms such as simple lipoma, pleomorphic adenoma, or oncocytoma.
    Clinical and Experimental Otorhinolaryngology 06/2014; 7(2):149-52. · 0.88 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Tongue squamous cell carcinoma (SCC) has an increasing incidence, a high morbidity rate, and a 50% 5-year survival rate. The prognosis of tongue SCC is poor compared to SCC originating at other sites in the oral cavity, because they represent different biological subentities. Cytogenetic studies of head and neck SCC showed more losses than gains of various chromosomes or chromosomal segments. Among the frequent alterations there are losses of -4, -10, -13, -14, -18, -19, -21, -22, gains of +7, +8, +9, +16, +18, +20, and isochromosomes i(1q), i(3q), i(5p), i(8q). We are unaware of cytogenetic reports describing t(12;14) in tongue SCC. This is a cytogenetic study of SCC of the tongue. Tongue biopsy tissue was minced and cultured in RPMI-1640 medium. Cells were fixed and stained, and cytogenetic analysis performed according to standard procedures. A clone with t(12;14) along with other random numerical chromosomal changes was found in a case of tongue SCC. The significance of t(12;14) in diagnosis or prognosis is not clear and should be further examined. Karyotyping of more tongue SCC cases will expand the knowledge regarding chromosomal aberrations in SCC and thus might shed light on the significance of t(12;14) shown in this study.
    Archives of Oto-Rhino-Laryngology 08/2010; 267(8):1273-6. · 1.29 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Oncocytic lipoadenoma is an exceedingly uncommon neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Retrospective. Seven cases of oncocytic lipoadenoma were analyzed in order to further characterize the clinical and pathologic features of this rare tumor. The patients included six males and one female who ranged from 40 to 83 years of age (mean 62 years) at presentation. All tumors arose in the parotid gland. Grossly, the tumors were solitary, well circumscribed and had light brown to yellow cut surfaces. Histologically, the tumors were composed of an admixed population of oncocytes and adipocytes in varying proportions, with the lipomatous component ranging from 5 to 70 %. Other common features included the presence of serous acini, ductal elements, sebaceous glands, and a patchy chronic inflammation. Clinical follow up information, available in all cases, with a duration of 3-148 months (mean 57 months), showed no evidence of tumor recurrence. Due to its rarity, oncocytic lipoadenoma can pose problems in diagnosis, although the distinctive morphologic features of this neoplasm allow for separation from more commonly recognized oncocytic neoplasms of the salivary glands.
    Head and Neck Pathology 04/2014;

Full-text (2 Sources)

View
85 Downloads
Available from
May 21, 2014