Epidemiology of interstitial lung diseases in Greece

2nd Department of Pneumonology, Medical School, University of Athens and "Attikon" University Hospital, Greece.
Respiratory medicine (Impact Factor: 3.09). 05/2009; 103(8):1122-9. DOI: 10.1016/j.rmed.2009.03.001
Source: PubMed


Few data are available on the epidemiology of interstitial lung diseases (ILDs), especially after the current classification of idiopathic interstitial pneumonias. The aim of this study is to provide data on the epidemiology of ILDs in Greece, under the ATS/ERS international consensus.
Departments of Pneumonology were contacted and asked to complete a questionnaire for every case of ILD that was alive on 2004 as well as for every new case from 1st January 2004 to 31st December 2004. Questions on the patients' demographic data, the exact diagnosis and the procedures used to establish the diagnosis were included. Centers covering about 60% of the Greek population have been analyzed.
A total of 967 cases have been registered. The estimated prevalence of ILDs is 17.3 cases per 100,000 inhabitants. The estimated annual incidence of ILDs is 4.63 new cases per 100,000 inhabitants. The most frequent disease is sarcoidosis (34.1%), followed in decreasing order by idiopathic pulmonary fibrosis (19.5%), ILD associated with collagen vascular diseases (12.4%), cryptogenic organizing pneumonia (5.3%), histiocytosis (3.8%), and hypersensitivity pneumonitis (2.6%). Unclassified ILD or not otherwise specified accounted for the 8.5% of prevalent cases.
These data suggest that sarcoidosis and idiopathic pulmonary fibrosis are the most frequent ILDs in our population. In comparison with the few previous reports, interesting dissimilarities have been observed.

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    • "Study Mean/median age at Dg Male/ Female Total no of cases/ ATS/ERS 2000/2002 Before ATS/ERS 2000/2002 Re-evaluation % IPF of ILD Dg criteria used Thomeer et al. 2001 57 years 58/42% 362/20% X Liebow 1975 Tinelli et al. 2005 68 years 63/37% 3152/27% X Xaubert et al. 2004 511/38.6% X Karakatsani et al. 2009 967/20% X Hodgson et al. 2002 X X von Plessen et al. 2003 69.2 45/55 X Turner-Warwick X Gribbin et al. 2006 71 years 62/38% X Raghu et al. 2006 X Olson et al. 2007 X Ohno et al. 2008 65 years 1543/85.7% X Fernández Pérez et al. 2010 74 years X X Navaratnam et al. 2011 74 years 63/37% X Lai et al. 2012 X "
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    • "Epidemiologic studies in Italy, Belgium, Greece, Spain, United States and Finland have revealed that the diagnosis has been confirmed by SLB in 28–38% of the cases [17-22]. Questionnaire-based national surveys have shown that in Greece and Spain approximately 31% of the patients with IPF were diagnosed by SLB [19,22]. In the major clinical trials conducted in the past decade, the current diagnostic criteria for IPF have been used which may provide some enlightenment on the frequency of SLB. "
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