Idiopathic and Primary Cardiomyopathies in Children.
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ABSTRACT: Cardiomyopathy is a serious disorder of the heart muscle and, although rare, is a common cause of heart failure in children and the most common cause for heart transplantation in children older than 1 year of age. Funded by the National Heart Lung and Blood Institute since 1994, the Pediatric Cardiomyopathy Registry (PCMR) has followed more than 3500 North American children with cardiomyopathy. Early analyses determined estimates for the incidence of pediatric cardiomyopathy (1.13 cases per 100,000 children per year), risk factors for cardiomyopathy (age <1 year, male sex, black race, and living in New England as opposed to the central southwestern states), the prevalence of heart failure at diagnosis (6%-84% depending on cause), and 10-year survival (29%-94% depending on cause). More recent analyses explored cause-specific functional status, survival and transplant outcomes, and risk factors in greater detail. For many topics these analyses are based on the largest and best-documented samples of children with disease such as the muscular dystrophies, mitochondrial disorders, and Noonan syndrome. Data from the PCMR continue to provide valuable information that guides clinical management and the use of life-saving therapies, such as cardiac transplantation and approaches to treating heart failure, and prepares children, their families, and their caregivers to deal with this serious condition.Heart Failure Clinics 10/2010; 6(4):401-13, vii.
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ABSTRACT: Hydrogen bonds and proton transfer play an important key role in hydrogen-bonded ferroelectrics phase transitions, in protein folding and conformation changes in DNA, and in the biomembrane's ion channels. In this presentation we analyze the possible mechanisms of proton subsystem's influence on the phase or conformation transition. Two main approaches are considered: 1) continuum condensed matter physics description-soliton models; 2) quantum-chemical ab initio calculations on the basis of Gaussian98 software. The main results of both representations are that at the first step of transition the protons cascade are arising with agreements of experimental observations. We discuss new possible quantum mechanism of this proton cascade and new effects in proton transfer in ferroelectrics and related systems.01/2002;
Idiopathic and Primary Cardiomyopathies in Children
Steven E. Lipshultz, Steven D. Colan, Jeffrey A. Towbin, and James D. Wilkinson
This is the third and final issue of Progress in Pediatric Cardiology that reports results from
the scientific conference on future research directions for children with idiopathic or primary
cardiomyopathies that was held in Bethesda, Maryland in January 2007. The conference was
sponsored by the Children's Cardiomyopathy Foundation and the National Heart, Lung and
Blood Institute with additional support from the Genzyme Corporation and the Department of
Pediatrics of Leonard M. Miller School of Medicine at the University of Miami. In this issue
we begin with the results from the expert roundtable discussions regarding future directions in
pediatric cardiomyopathy research in the areas of genetics, epidemiology and clinical care.
Topics in this issue include an update on the NHLBI funded Pediatric Cardiomyopathy
Registry, stem cell therapies, signalosomes, familial dilated cardiomyopathy, cardiomyopathy
related to fatty acid metabolism, peripartum and restrictive cardiomyopathy, and exercise
rehabilitation and comprehensive care for children with cardiomyopathy.
The editors wish to acknowledge the outstanding support of the Children’s Cardiomyopathy
Foundation (CCF) and its president and founder Ms. Lisa Yue for continuing and unwavering
support for pediatric cardiomyopathy research. Ms. Yue, with the CCF, has been the primary
proponent and principal financial underwriter of the January 2007 conference held in Bethesda
noted above. We also wish to recognize Pauline Pierrot and Talitha Hill from CCF whose
considerable efforts made the conference possible, as well as the financial support from the
Genzyme Corporation. Also, the editors wish to express their gratitude to Ms. Mitzi Wilkinson,
Ms. Kathryn Deane, Mr. Jorge Alvarez, and Ms. Natalya Bublik from the Department of
Pediatrics of Leonard M. Miller School of Medicine at the University of Miami for their
invaluable efforts in the planning, conduct and dissemination of the results of this important
conference. Finally, we wish to thank Dr. Gail Pearson and Dr. Pothur R. Srinivas of the
National Heart, Lung and Blood Institute for their expertise and support for the Bethesda
E-mail address: firstname.lastname@example.org (S.E. Lipshultz).
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Prog Pediatr Cardiol. Author manuscript; available in PMC 2009 April 1.
Published in final edited form as:
Prog Pediatr Cardiol. 2008 April ; 25(1): 1.
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