Exposure to Mouse Allergen in U.S. Homes Associated with Asthma Symptoms

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Environmental Health Perspectives (Impact Factor: 7.98). 03/2009; 117(3):387-91. DOI: 10.1289/ehp.11847
Source: PubMed


Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations.
We examined whether elevated mouse allergen levels were associated with occupants' asthma status in a nationally representative sample of U.S. households.
Data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed 831 housing units inhabited by 2,456 individuals in 75 different locations throughout the United States. The survey obtained information on demographics, household characteristics, and occupants' health status by questionnaire and environmental observations. We used a polyclonal immunoassay to assess concentrations of mouse urinary protein (MUP) in vacuumed dust collected from various indoor sites.
Of the surveyed homes, 82% had detectable levels of MUP, and in 35% of the homes, MUP concentrations exceeded 1.6 microg/g, a level that has been associated with increased mouse allergen sensitization rates. Current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated with increased MUP levels. The observed association was modified by atopic status; in allergic individuals, elevated MUP levels (>1.6 microg/g) increased the odds of having asthma symptoms [adjusted OR=1.93; 95% confidence interval (CI), 1.14-3.27], but we found no association in those who did not report allergies (adjusted OR=0.69; 95% CI, 0.33-1.44).
In allergic asthma, residential mouse allergen exposure is an important risk factor for asthma morbidity.

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    • "Grandes structures* 97% 31.8 282,2 [4] [6-6454] [2] Petites structures* "
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    ABSTRACT: Indoor allergen exposure is implicated in allergic respiratory disease and contributes to asthma morbidity. Mouse allergen plays a role in allergic asthma morbidity. However, no study is available on the distribution of this allergen in French public buildings.Methods Forty-six dust samples, collected by vacuuming during 2 different seasons, on the floor of five French public buildings in PACA region. They were divided into two subgroups (small and big structures), allowed to analyze five indoor allergens, with Multiplex ARray for Indoor Allergens™. A visual inspection and a questionnaire about the building and rooms were performed.ResultsMus m1, Fel d1, Can f1, Bla g2, Rat n1 were found in 93%, 87%, 61%, 35% and 7% of the dust samples with a median concentration (range) at 19.6 ng/g (0.2–6454.2), 37.9 ng/g (2.4–841.2), 28.2 ng/g (2.4–484.8), 188 ng/g (20.8–527.8) and 3.8 ng/g (3.8–12.8), respectively. All these allergens were positively correlated two by two, except for Mus m1. In the small and big structures, the median level of Mus m1 is 0.5 ng/g and 31.8 ng/g, respectively (P < 0.0001). Rat n1 was only present in big structures, with a median level at 3.8 ng/g. Deratting was more often used in big structures (P < 0.005). Mouse droppings were not associated with detection of Mus m1.Conclusion The prevalence of mouse allergen was substantial but their levels were most often very low. Mus m1 does not appear a major risk factor for asthma morbidity in PACA region.
    Revue Française d'Allergologie 11/2014; 55(1). DOI:10.1016/j.reval.2014.09.002 · 0.25 Impact Factor
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    • "Rodents allergens, especially those of M and to a lesser extent those of Rt, represent a common cause of allergic sensitization and bronchial asthma in children and adult population of US living in inner cities [2,5]. It has been shown that current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated to increasing levels of M allergens at home [3]. Recently, Tojusen et al. [23] have shown that every tenfold increase in the bed mouse allergen level was associated with an 87% increase in the odds of any asthma-related health care use among mouse-sensitized, but not among non-mouse-sensitized participants. "
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    Multidisciplinary respiratory medicine 04/2013; 8(1):30. DOI:10.1186/2049-6958-8-30 · 0.15 Impact Factor
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    • "As importantly, studies of environmental factors in relation to asthma morbidity frequently focus on only a subset of exposures. Certain studies of indoor environmental exposures have emphasized specific allergens, such as from house dust mites, pets, cockroach, and rodents [1-5] or inflammatory agents such as endotoxin or glucans [6]. Others have focused on other indoor factors, such as secondhand smoke [7,8], dampness [9], or combustion heating and cooking sources [10]. "
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    Environmental Health 05/2010; 9(1):24. DOI:10.1186/1476-069X-9-24 · 3.37 Impact Factor
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