Plateletworks: A screening assay for clopidogrel therapy monitoring in healthy cats

Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Québec, Canada.
Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire (Impact Factor: 1.02). 01/2009; 73(1):73-6.
Source: PubMed


Plateletworks is a screening assay used in human medicine to monitor platelet-inhibiting drugs. As arterial thromboembolism is a common complication in cats suffering from cardiomyopathy, they are often treated with anti-platelet medication. Clopidogrel (Plavix), an anti-platelet aggregation drug, has recently been evaluated in healthy cats. The purpose of this study was to determine if the Plateletworks method can detect a decrease in platelet aggregation in cats receiving clopidogrel. Nine healthy adult cats were used for this study. Platelet aggregation was measured before and after a 3-day clopidogrel treatment (18.75 mg SID). Platelet aggregation after the clopidogrel treatment was significantly lower (P < 0.01). The Plateletworks method appears to be a promising test to monitor clopidogrel therapy in cats.

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Available from: Christian Bedard, Aug 13, 2014
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