Article

Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth

The Roslin Institute and Royal School of Veterinary Studies, The University of Edinburgh, Midlothian, UK.
Cell Biochemistry and Function (Impact Factor: 2.13). 04/2009; 27(3):119-27. DOI: 10.1002/cbf.1551
Source: PubMed

ABSTRACT Longitudinal bone growth is a tightly regulated process that relies on complex synchronized mechanisms at the growth plate. Chronic paediatric inflammatory diseases are well accepted to lead to growth retardation and this is likely due to raised inflammatory cytokine levels and reduced growth hormone (GH)/insulin-like growth factor-1 (IGF-I) signalling. The precise cellular mechanisms responsible for this inhibition are unclear and therefore in this article, we will review the potential interactions between inflammatory cytokines and the GH/IGF-I axis in the regulation of bone growth. In particular, we will emphasis the potential contribution of the suppressors of cytokine signalling (SOCS) proteins, and in particular SOCS2, in mediating this process.

0 Followers
 · 
97 Views
  • Nephrology Dialysis Transplantation 03/2010; 25(3):658-60. DOI:10.1093/ndt/gfp769 · 3.49 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Patients with the more severe forms of epidermolysis bullosa (EB) are at risk of developing osteopenia, osteoporosis and fractures. The cause is likely to be multifactorial and includes reduced mobility, a generally proinflammatory state, poor nutrition and hormonal factors. Monitoring this group with dual energy X-ray absorptiometry (DEXA) scans and plain radiographs is necessary to detect these changes. Data are lacking about the optimal approach to managing poor bone health in EB, although it seems that encouraging mobility, supplementation of calcium and vitamin D where necessary, with the addition of a bisphosphonate when there is evidence of fractures, may be helpful.
    Dermatologic clinics 04/2010; 28(2):353-5, xi. DOI:10.1016/j.det.2010.01.006 · 1.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Puberty is the acquisition of secondary sexual characteristics, associated with a growth spurt, resulting in the attainment of reproductive function and final adult height. Delayed puberty is defined as the absence of any pubertal development at an age 2 standard deviations (SD) more than the mean, which corresponds to an age of approximately 14 years for boys and 13 years for girls. The degree to which growth and pubertal development are affected in chronic illness depends on the disease itself, as well as factors such as age of onset, duration and severity; the earlier the onset and the more severe the disease, the greater the effect on growth and pubertal development. Most children with severe types of epidermolysis bullosa have abnormal growth and pubertal delay. The possible pathophysiology is discussed.
    Dermatologic clinics 04/2010; 28(2):357-9, xii. DOI:10.1016/j.det.2010.01.007 · 1.43 Impact Factor