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Prevent Alzheimer's Disease by 2020: A National Strategic Goal

Alzheimer's & dementia: the journal of the Alzheimer's Association (Impact Factor: 17.47). 04/2009; 5(2):81-4. DOI: 10.1016/j.jalz.2009.01.022
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    ABSTRACT: Low-cost and compact modules require appropriate multilayer substrates. In applications up to 24 GHz LTCC (Low Temperature Cofired Ceramics) tapes are successfully used but in the range from 60 to 110 GHz and especially in antenna design the high relative permittivity of LTCC is a strong constraint. In this paper a new progressive and inhomogeneous method of material modulation enabling radiation and optimising the radiation pattern by setting a calculated permittivity profile is presented for LTCC-multilayer antenna design. The method is applied to the design of a vivaldi antenna at 76.5 GHz integrated into a compact LTCC-multilayer near field radar sensor module [4]. By calculating the optimum permittivity profile the radiation pattern and matching have been optimised as well as the antenna size. The excellent results in the antenna design are verified and a measurement example with the radar sensor is presented.
    Microwave Conference, 2003. 33rd European; 11/2003
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    ABSTRACT: Background: Several studies performed in European populations have demonstrated that the C766T polymorphism (exon 3) of low-density lipoprotein receptor-related protein gene (LRP1) is associated with several vascular diseases as Alzheimer and coronary artery disease (CAD). Nevertheless, the results obtained are contradictory. Thus, the aim of the present study was to evaluate the possible contribution of this genetic variant to the development of CAD in subjects from Southern Chile. Methods: A total of 113 unrelated patients with diagnosis of CAD documented by angiography (33 – 74 years old), and 112 healthy controls (30 – 68 years old) were included in this study. The C766T polymorphism at the LRP1 gene was analyzed by PCR-RFLP. The serum levels of glucose, uric acid and lipids were determined by enzymatic colorimetric methods. Results: The genotype distribution of C766T polymorphism of LRP1 gene in subjects with CAD (CC: 87%, CT: 11%, TT: 2%) and controls (CC: 88%, CT: 12%, TT: 0%) was similar (p=0.362). Similarly, the relative allelic frequency in CAD patients (C: 0.92, T: 0.08) and controls (C: 0.94, T: 0.06) was comparable (p=0.729). Moreover, the Odds Ratio (OR) was 1.36 (95%CI: 0.48 - 3.83; p=NS). In addition, the C766T polymorphism of LRP1 gene was not associated with variations on serum lipid and glucose levels. Conclusion: These findings suggest that the C766T polymorphism of the LRP1 gene not contributed to CAD in the studied population.
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    ABSTRACT: Background: Several studies performed in European populations have demonstrated that the C766T polymorphism (exon 3) of low-density lipoprotein receptor-related protein gene (LRP1) is associated with several vascular diseases as Alzheimer and coronary artery disease (CAD). Nevertheless, the results obtained are contradictory. Thus, the aim of the present study was to evaluate the possible contribution of this genetic variant to the development of CAD in subjects from Southern Chile. Methods: A total of 113 unrelated patients with diagnosis of CAD documented by angiography (33 - 74 years old), and 112 healthy controls (30 - 68 years old) were included in this study. The C766T polymorphism at the LRP1 gene was analyzed by PCR-RFLP. The serum levels of glucose, uric acid and lipids were determined by enzymatic colorimetric methods. Results: The genotype distribution of C766T polymorphism of LRP1 gene in subjects with CAD (CC: 87%, CT: 11%, TT: 2%) and controls (CC: 88%, CT: 12%, TT: 0%) was similar (p=0.362). Similarly, the relative allelic frequency in CAD patients (C: 0.92, T: 0.08) and controls (C: 0.94, T: 0.06) was comparable (p=0.729). Moreover, the Odds Ratio (OR) was 1.36 (95%CI: 0.48 - 3.83; p=NS). In addition, the C766T polymorphism of LRP1 gene was not associated with variations on serum lipid and glucose levels. Conclusion: These findings suggest that the C766T polymorphism of the LRP1 gene not contributed to CAD in the studied population.
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