Article

[Cognitive impairment and parkinsonism due to use of sodium valproate].

Klinisch geriater in opleiding, Afdeling geriatrie, Universitair Medisch Centrum St Radboud, Nijmegen.
Tijdschrift voor gerontologie en geriatrie 03/2009; 40(1):29-33. pp.29-33
Source: PubMed

ABSTRACT Two patients presented with progressive cognitive impairment and parkinsonism related symptoms while being treated with sodium valproate. Both patients suffered from progressive cognitive decline and mobility disorders with an insidious onset over a period of months to years. After discontinuation of sodium valproate both debilitating symptoms resolved nearly completely. There is a growing prevalence and incidence of epilepsy above the age of 60 and a great number of these patients are on sodium valproate treatment. All clinicians treating elderly patients should be aware of the fact that this treatment can cause reversible cognitive decline and parkinsonism probably due to impairment of mitochondrial complex I function. Discontinuation of sodium valproate is strongly recommended in all patients with development of cognitive impairment or parkinsonism or both during sodium valproate treatment.

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Keywords

clinicians
 
cognitive impairment
 
debilitating symptoms
 
Discontinuation
 
elderly patients
 
great number
 
growing prevalence
 
insidious onset
 
mitochondrial complex
 
mobility disorders
 
patients
 
progressive cognitive decline
 
progressive cognitive impairment
 
sodium valproate
 
sodium valproate treatment
 
symptoms