Article

Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction

Departments of Psychiatry and Behavioral Sciences and Medicine, Duke University, Durham, NC, USA.
American Journal of Clinical Nutrition (Impact Factor: 6.92). 04/2009; 89(5):1315-20. DOI: 10.3945/ajcn.2008.26829
Source: PubMed

ABSTRACT n-3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n-3 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction (AMI) patients-a group at elevated risk of malignant arrhythmias.
The objective was to examine the association between n-3 fatty acid consumption and ventricular ectopy among AMI patients.
In 260 AMI patients, dietary intake of n-3 fatty acids was assessed by using the Harvard food-frequency questionnaire, and ventricular ectopy was estimated from 24-h electrocardiograph recordings.
A greater intake of n-3 fatty acids (eicosapentaenoic acid + docosahexaenoic acid + docosapentaenoic acid + alpha-linolenic acid) was associated with lower ventricular ectopy (beta = -0.35, P = 0.011), and this effect remained after cardiovascular comorbidities were controlled for (beta = -0.47, P = 0.003). Higher concentrations of both marine-based (eicosapentaenoic acid + docosahexaenoic acid) (beta = -0.21, P = 0.060) and plant-based (alpha-linolenic acid) (beta = -0.33, P = 0.024) fatty acids remained associated with lower ventricular ectopy after cardiovascular comorbidities were controlled for.
These findings extend existing evidence linking n-3 fatty acid consumption to a reduced risk of ventricular arrhythmias by showing that a greater intake of n-3 fatty acids may be associated with low ventricular ectopy among AMI patients.

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    Cardiovascular health and chronomics, Edited by Ram B Singh, 01/2014: chapter The Gut, Brain, and Heart Connection; Nova Science Publishers, Inc, New York.
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    Omega-3 Fatty Acids. Chemistry, Dietary Sources and Health Effects, Edited by Wasim Khan, 01/2014: chapter 3: pages 37-61; Nova Publishing., ISBN: 978-1-62948-516-4
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