Reducing indoor air pollution by air conditioning is associated with improvements in cardiovascular health among the general population

Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan.
Science of The Total Environment (Impact Factor: 4.1). 06/2013; 463-464C:176-181. DOI: 10.1016/j.scitotenv.2013.05.093
Source: PubMed

ABSTRACT Indoor air pollution is associated with cardiovascular effects, however, little is known about the effects of improving indoor air quality on cardiovascular health. The aim of this study was to explore whether improving indoor air quality through air conditioning can improve cardiovascular health in human subjects. We recruited a panel of 300 healthy subjects from Taipei, aged 20 and over, to participate in six home visits each, to measure a variety of cardiovascular endpoints, including high sensitivity-C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), fibrinogen in plasma and heart rate variability (HRV). Indoor particles and total volatile organic compounds (VOCs) were measured simultaneously at the participant's home during each visit. Three exposure conditions were investigated in this study: participants were requested to keep their windows open during the first two visits, close their windows during the next two visits, and close the windows and turn on their air conditioners during the last two visits. We used linear mixed-effects models to associate the cardiovascular endpoints with individual indoor air pollutants. The results showed that increases in hs-CRP, 8-OHdG and fibrinogen, and decreases in HRV indices were associated with increased levels of indoor particles and total VOCs in single-pollutant and two-pollutant models. The effects of indoor particles and total VOCs on cardiovascular endpoints were greatest during visits with the windows open. During visits with the air conditioners turned on, no significant changes in cardiovascular endpoints were observed. In conclusion, indoor air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction. Reductions in indoor air pollution and subsequent improvements in cardiovascular health can be achieved by closing windows and turning on air conditioners at home.

Download full-text


Available from: Hsiao-Chi Chuang, Apr 17, 2014
1 Follower
78 Reads
  • Source
    • "It is well documented in the literature that reductions in indoor air pollution and subsequent improvements in cardiovascular health can be achieved by filtration of recirculated indoor air, closing windows and turning on air conditioners at home [38],[42]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: Various air pollutants are found in several interior environments, sometimes at increased concentrations, and they negatively affect the indoor air quality. Exposure to these pollutants often contributes to structural degradation and building failures within their indoor environment and can lead to numerous immediate and long-term health problems. Aim: This retrospective study provides a comprehensive review of the new evidence linking indoor air quality with its impact on respiratory and cardiovascular system. It also refers to the principal pollutants found in indoor environments and associated with harmful effects on health. Method: A review of the Greek and international literature on the issue was performed through the electronic databases Pubmed, Google Scholar, Scopus and scientific journals, using the following key words: Indoor Air Quality, Indoor Air Pollution, Cardiovascular disease, Respiratory disease, Risk factors Results: Indoor air pollution increases the risk of chronic obstructive pulmonary disease, causes or contributes to the development of acute respiratory infections, lung cancer, and chronic lung diseases such as asthma and it has also been associated with many cardiovascular diseases. Conclusion: The indoor air quality is a significant factor in maintaining good health. Understanding of the harmful effects induced by indoor air pollution will help us to take all the appropriate preventive measures to reduce the possible health risks.
    International Journal of Advances in Engineering Sciences and Applied Mathematics 08/2015; 2(8):11-14.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Previous studies have associated ambient particulate chemical constituents with adverse cardiopulmonary health effects. However, specific pollution sources behind the cardiopulmonary health effects of ambient particles are uncertain. We examined the cardiopulmonary health effects of fine particles (PM2.5) from different pollution sources in Beijing, China, among a panel of 40 healthy university students. Study subjects were repeatedly examined for a series of cardiopulmonary health indicators during three 2-month-long study periods (suburban period, urban period 1, and urban period 2) in 2010−2011 before and after relocating from a suburban campus to an urban campus with changing air pollution levels and contents. Daily ambient PM2.5 mass samples were collected over the study and measured for 29 chemical constituents in the laboratory. Source appointment for ambient PM2.5 was performed using Positive Matrix Factorization, and mixed-effects models were used to estimate the cardiopulmonary effects associated with source-specific PM2.5 concentrations. Seven PM2.5 sources were identified as traffic emissions (12.0%), coal combustion (22.0%), secondary sulfate/nitrate (30.2%), metallurgical emission (0.4%), dust/soil (12.4%), industry (6.9%), and secondary organic aerosol (9.9%). Ambient PM2.5 in the suburban campus had larger contributions from secondary sulfate/nitrate (41.8% vs. 22.9%−26.0%) and metallurgical emission (0.7% vs. 0.3%) as compared to that in the urban campus), whereas PM2.5 in the urban campus had larger contributions from traffic emissions (13.0%−16.3% vs. 5.1%), coal combustion (21.0%−30.7% vs. 10.7%), and secondary organic aerosol (9.7%−12.0% vs. 8.7%) as compared to that in the suburban campus. Potential key sources were identified for PM2.5 effects on inflammatory biomarkers (secondary sulfate/nitrate and dust/soil), blood pressure (coal combustion and metallurgical emission), and pulmonary function (dust/soil and industry). Analyses using another source appointment tool Unmix yielded a similar pattern of source contributions and associated health effects. In conclusion, ambient PM2.5 in Beijing suburban and urban areas has two distinct patterns of source contributions, and PM2.5 from different sources may play important roles on different aspects of PM2.5-related cardiopulmonary health effects.
    Environmental Science & Technology 02/2014; DOI:10.1021/es404778w · 5.33 Impact Factor
  • Source
    Wildfire and smoke guidelines, Edited by Catherine T Elliott, Karen Rideout, 03/2014; British Columbia Centre for Disease Control.
Show more