Article

Primary and secondary T-cell lymphomas of the breast: clinico-pathologic features of 11 cases.

Consultoria em Patologia, Botucatu, Sao Paulo, Brazil.
Applied immunohistochemistry & molecular morphology: AIMM / official publication of the Society for Applied Immunohistochemistry (impact factor: 1.63). 04/2009; 17(4):301-6. DOI:10.1097/PAI.0b013e318195286d pp.301-6
Source: PubMed

ABSTRACT Breast involvement by non-Hodgkin lymphomas is rare, and exceptional for T-cell lymphomas; we studied the morphologic, immunophenotypic, and clinical features of 11 patients with T-cell non-Hodgkin lymphomas involving the breast. Four cases fulfilled the definition criteria for primary breast lymphomas, 3 females and 1 male, with a median age of 51 years. One primary breast lymphomas was T-cell lymphoma unspecified, other was subcutaneous panniculitis-like T-cell lymphoma, and 2 cases were anaplastic large cell lymphomas. One of the anaplastic large cell lymphoma cases was found surrounding a silicone breast implant and presented as clinically as mastitis; whereas the other case occurred in a man. T-cell lymphoma secondarily involved the breast in 7 patients, all women and 1 bilateral, with a median age of 29 years. These secondary breast lymphomas occurred as part of widespread nodal or leukemic disease. Three patients had adult T-cell leukemia/lymphoma, including the patient with bilateral lesions, 3 others had precursor T-lymphoblastic lymphoma/leukemia, and the other presented with a peripheral-T-cell lymphoma non otherwise specified type. Breast T-cell lymphomas are very infrequent and are morphologically and clinically heterogeneous.

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    Article: Anaplastic large cell lymphoma and breast implants: results from a structured expert consultation process.
    Benjamin Kim, Carol Roth, V Leroy Young, Kevin C Chung, Kristin van Busum, Christopher Schnyer, Soeren Mattke
    [show abstract] [hide abstract]
    ABSTRACT: There are increasing concerns about a possible association between anaplastic large cell lymphoma (ALCL) and breast implants. The authors conducted a structured expert consultation process to evaluate the evidence for the association, its clinical significance, and a potential biological model based on their interpretation of the published evidence. A multidisciplinary panel of 10 experts was selected based on nominations from national specialty societies, academic department heads, and recognized researchers in the United States. Panelists agreed that (1) there is a positive association between breast implants and ALCL development but likely underrecognition of the true number of cases; (2) a recurrent, clinically evident seroma occurring 6 months or more after breast implantation should be aspirated and sent for cytologic analysis; (3) anaplastic lymphoma kinase-negative ALCL that develops around breast implants is a clinically indolent disease with a favorable prognosis that is distinct from systemic anaplastic lymphoma kinase-negative ALCL; (4) management should consist of removal of the involved implant and capsule, which is likely to prevent recurrence, and evaluation for other sites of disease; and (5) adjuvant radiation or chemotherapy should not be offered to women with capsule-confined disease. Little agreement, however, was found regarding etiologic risk factors for implant-associated ALCL. The authors' assessment yielded consistent results on a number of key issues regarding ALCL in women with breast implants, but substantial further research is needed to improve our understanding of the epidemiology, clinical aspects, and biology of this disease. Risk, V.
    Plastic and reconstructive surgery 05/2011; 128(3):629-39. · 2.74 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

2 cases
 
3 females
 
3 others
 
7 patients
 
anaplastic large cell lymphoma cases
 
Breast involvement
 
Breast T-cell lymphomas
 
clinically heterogeneous
 
definition criteria
 
leukemic disease
 
median age
 
non-Hodgkin lymphomas
 
peripheral-T-cell lymphoma non
 
primary breast lymphomas
 
secondary breast lymphomas
 
silicone breast implant
 
T-cell lymphoma secondarily
 
T-cell lymphomas
 
T-cell non-Hodgkin lymphomas
 
widespread nodal