Primary and Secondary T-cell Lymphomas of the Breast

Consultoria em Patologia, Botucatu, Sao Paulo, Brazil.
Applied immunohistochemistry & molecular morphology: AIMM / official publication of the Society for Applied Immunohistochemistry (Impact Factor: 2.01). 04/2009; 17(4):301-6. DOI: 10.1097/PAI.0b013e318195286d
Source: PubMed


Breast involvement by non-Hodgkin lymphomas is rare, and exceptional for T-cell lymphomas; we studied the morphologic, immunophenotypic, and clinical features of 11 patients with T-cell non-Hodgkin lymphomas involving the breast. Four cases fulfilled the definition criteria for primary breast lymphomas, 3 females and 1 male, with a median age of 51 years. One primary breast lymphomas was T-cell lymphoma unspecified, other was subcutaneous panniculitis-like T-cell lymphoma, and 2 cases were anaplastic large cell lymphomas. One of the anaplastic large cell lymphoma cases was found surrounding a silicone breast implant and presented as clinically as mastitis; whereas the other case occurred in a man. T-cell lymphoma secondarily involved the breast in 7 patients, all women and 1 bilateral, with a median age of 29 years. These secondary breast lymphomas occurred as part of widespread nodal or leukemic disease. Three patients had adult T-cell leukemia/lymphoma, including the patient with bilateral lesions, 3 others had precursor T-lymphoblastic lymphoma/leukemia, and the other presented with a peripheral-T-cell lymphoma non otherwise specified type. Breast T-cell lymphomas are very infrequent and are morphologically and clinically heterogeneous.

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Available from: Lawrence M Weiss, Nov 04, 2014
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    • "The commonest histologies are DLBCL (56–84% of PBL) [4] [5] [8] [9] [28] [50], MZL (9–28%) [2] [5] [25] [28] [51], follicular (10–19%) [2] [9] [51], and Burkitt lymphoma (<6%) [50] [52] [53]. Rarer histologies include anaplastic large cell lymphoma [54], peripheral T-cell lymphoma [55] [56], small lymphocytic lymphoma [2] [25], lymphoplasmacytic lymphoma [2], mantle cell lymphoma [57] [58] [59] and Hodgkin lymphoma (each < 1%) [5]. Here we present an overview of the more important rare subtypes , followed by more detailed evaluation of the pathology and clinical aspects of PB-DLBCL. "
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    ABSTRACT: Primary breast lymphoma is a rare form of extranodal lymphoma, defined by the presence of a primary lesion within the breast with or without regional nodal involvement but no other extra-mammary sites of involvement. It comprises diverse histologic subtypes, but diffuse large B-cell lymphoma is the most common. In this review, we describe in detail the clinical features, diagnosis and staging, pathogenesis, risk factors and therapy of primary breast diffuse large B-cell lymphoma. We consider choice and number of cycles of chemotherapy, the indications for radiotherapy and discuss the need for central nervous system prophylaxis. We also provide a brief overview of the less commonly encountered histologic subtypes including marginal zone, follicular, Burkitt and breast implant associated anaplastic large cell lymphoma. We conclude with a suggested treatment approach and potential areas of future research.
    Cancer Treatment Reviews 09/2014; 40(8). DOI:10.1016/j.ctrv.2014.05.010 · 7.59 Impact Factor
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    • "PTBL is an extremely rare and aggressive disease. The age range of patients with this disease is between 13 and 77 years old (3,7). The most common subtype of peripheral T-cell lymphoma is unspecified, accounting for ~50% of all cases. "
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    ABSTRACT: The current study presents a case of primary T-cell lymphoma (PTBL), unspecified, in a 27-year-old female. The patient received chemotherapy [cyclophosphamide, epirubicin, vindesine and prednisolone (CHOP) and VP-16 plus CHOP (ECHOP)] and autologous peripheral blood stem cell transplantation, however, relapse occurred rapidly. The recurrent tumor exhibited increased levels of karyopyknosis and nuclear fragmentation and a higher Ki67 index compared with the primary tumor. No response to subsequent chemotherapy, including ECHOP and gemcitabine, dexamethasone and cisplatin, was observed. The patient succumbed to PTBL, unspecified, 18 months after the diagnosis. We hypothesize that autologous peripheral blood stem cell transplantation is ineffective for PTBL.
    Oncology letters 01/2014; 7(1):156-158. DOI:10.3892/ol.2013.1676 · 1.55 Impact Factor
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    • "Both patients (100%) with subcutaneous nodules and two of the three patients (67%) with skin thickening were found to have T-cell lymphoma on pathological examination. Therefore, skin or subcutaneous changes were more common in T-cell lymphoma, which is consistent with the findings of the previous study [18]. "
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    ABSTRACT: Hematological malignancies rarely affect the breast, and the majority of those that do are lymphomas. In this review, we describe the clinical aspects and multimodal imaging findings of breast lymphoma. We also illustrate the key clinical and radiological findings that allow it to be distinguished from various other malignant and benign diseases of the breast. Breast lymphoma manifests as a breast mass, a change in the subcutaneous tissue or the skin, or enlargement of the associated lymph node on radiological examination. Radiological findings associated with other breast malignancies, such as calcifications, spiculations, or architectural distortions are extremely rare. Skin and subcutaneous changes frequently accompany T-cell lymphoma. Multimodal breast imaging characteristics may aid in the diagnosis of breast lymphoma.
    Journal of Breast Cancer 09/2013; 16(3):254-265. DOI:10.4048/jbc.2013.16.3.254 · 1.58 Impact Factor
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