Article

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus.

Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia.
Nature Immunology (Impact Factor: 24.97). 04/2009; 10(5):524-30. DOI: 10.1038/ni.1718
Source: PubMed

ABSTRACT Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.

0 Bookmarks
 · 
115 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The skin is colonized by an assemblage of microorganisms which, for the most part, peacefully coexist with their hosts. In some cases, these communities also provide vital functions to cutaneous health through the modulation of host factors. Recent studies have illuminated the role of anatomical skin site, gender, age, and the immune system in shaping the cutaneous ecosystem. Alterations to microbial communities have also been associated with, and likely contribute to, a number of cutaneous disorders. This review focuses on the host factors that shape and maintain skin microbial communities, and the reciprocal role of microbes in modulating skin immunity. A greater understanding of these interactions is critical to elucidating the forces that shape cutaneous populations and their contributions to skin homeostasis. This knowledge can also inform the tendency of perturbations to predispose and/or bring about certain skin disorders.
    Cellular and Molecular Life Sciences CMLS 12/2014; · 5.86 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Domestic pigs are considered as a valuable large animal model because of their close relation to humans in regard to anatomy, genetics and physiology. This includes their potential use as organ donors in xenotransplantation but also studies on various zoonotic infections affecting pigs and humans. Such work also requires a thorough understanding of the porcine immune system which was partially hampered in the past by restrictions on available immunological tools compared to rodent models. However, progress has been made during recent years in the study of both, the innate and the adaptive immune system of pigs. In this review we will summarize the current knowledge on porcine αβ T cells, which comprise two major lymphocyte subsets of the adaptive immune system: CD4(+) T cells with important immunoregulatory functions and CD8(+) T cells, also designated as cytolytic T cells. Aspects on their functional and phenotypic differentiation are presented. In addition, we summarize currently available tools to study these subsets which may support a more widespread use of swine as a large animal model. Copyright © 2014 Elsevier Ltd. All rights reserved.
    Molecular Immunology 11/2014; · 3.00 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of infection, while the virus is confined to the lung mucosa, provides the ideal window of opportunity for an effective immune response to control the infection. Tissue-resident memory (Trm) CD8 T cells, located in a variety of tissues including the lung, are ideally situated to act during this window and stall the infection. The factors involved in the differentiation of lung Trm cells remain poorly defined. We demonstrate that recognition of antigen presented locally by dendritic cells (DCs) and transforming growth factor-β (TGFβ) signaling are both required. We exploited this knowledge to develop an antibody-targeted vaccination approach to generate lung Trm cells. Delivering antigen exclusively to respiratory DCs results in the development of lung CD8 Trm cells that are highly protective against lethal influenza challenge. Our results describe an effective vaccination strategy that protects against influenza virus infection.Mucosal Immunology advance online publication, 14 January 2015; doi:10.1038/mi.2014.133.
    Mucosal Immunology 01/2015; · 7.54 Impact Factor

Full-text (2 Sources)

Download
27 Downloads
Available from
Jun 2, 2014