Osteoclastlike giant cell tumor of the salivary gland

Department of Pathology, SUNY at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA.
Annals of diagnostic pathology (Impact Factor: 1.12). 05/2009; 13(2):114-8. DOI: 10.1016/j.anndiagpath.2007.06.009
Source: PubMed


Giant cell tumor of the salivary gland is extremely rare, with only 15 cases published in the English literature. The tumor characteristically contains a mixture of multinucleated giant cells, resembling osteoclasts of bone, and neoplastic mononuclear cells. In about half of the reported cases, there is an associated carcinomatous component. We are reporting an additional case of giant cell tumor of the parotid gland that was initially misinterpreted as an extraosseous osteosarcoma in the biopsy specimen. The histologic and immunohistochemical findings as well as a review of the literature with discussion of the histogenesis of this unusual neoplasm are presented.

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    • "Primary GCTPs were first described by Eusebi et al in 1984 (4), however, due to their rarity, there is an absence of literature that has analysed GCTP and all published material has been case reports. A summary of fifteen case reports, located using PubMed in a search of data up to May 2012, are presented in Table I(4–13). The most common clinical presentation of a GCTP was a non-tender, growing mass over the preauricular area followed by swelling of the parotid gland. "
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    ABSTRACT: A giant cell tumour (GCT) is a benign tumour that commonly arises in the distal end of the long bones. Extraosseous GCTs have been reported in a number of organs, but it is rare for a GCT to present in the parotid gland. Therefore, primary GCTs of the parotid gland (GCTPs) are extremely rare. Although GCTPs have been identified as benign soft-tissue tumours, they have a highly malignant potential and poor prognosis. In the present case, we report a 58-year-old male patient presenting with non-tender mass over the left preauricular area for 11 months. The final pathology report revealed a rare case of a GCTP that was treated by parotidectomy and adjuvant radiation therapy. The patient had no recurrence after 2 years of follow-up.
    Oncology letters 09/2013; 6(3):829-832. DOI:10.3892/ol.2013.1462 · 1.55 Impact Factor
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    ABSTRACT: Salivary gland carcinosarcoma is a rare neoplasm in which both stromal and epithelial components meet the microscopic criteria for malignancy. Seventy-four cases have been reported in English-language literature to date. In this study, we describe the case of an 81-year-old male patient with parotid gland carcinosarcoma featuring foci of undifferentiated carcinoma and sarcomatous components such as chondrosarcoma, high-grade undifferentiated sarcoma, and malignant giant cell tumor. We reviewed and discussed this rare occurrence of salivary gland carcinosarcoma with areas of malignant giant cell tumor, which had been reported only twice previously.
    Jornal Brasileiro de Patologia e Medicina Laboratorial 04/2012; 48(2):129-134. DOI:10.1590/S1676-24442012000200010
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    ABSTRACT: The giant cell tumor of the salivary gland is very rare, and 20 cases have been reported in the English-language literature. We report an additional case. A 57-year old man had noticed a mass in the right parotid area for several weeks. The diagnosis using aspiration cytology was a giant cell tumor possibly with a carcinomatous component. Superficial parotidectomy was carried out. The resected parotid gland contained a 1.8 cm-sized well-circumscribed brownish tumor. Histologically the tumor consisted of evenly distributed osteoclast-like giant cells, mononuclear cells and two small foci of a carcinomatous component. The osteoclast-like giant cells and mononuclear cells were positive for vimentin and CD68, and the carcinomatous component was positive for cytokeratin and epithelial membrane antigen. There was no metastatic lesion in the cervical lymph nodes. We believe this is the first case in Korea of an osteoclast-like giant cell tumor of the parotid gland.
    06/2012; 46(3):297-301. DOI:10.4132/KoreanJPathol.2012.46.3.297
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