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Osteoclastlike giant cell tumor of the salivary gland.

Department of Pathology, SUNY at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA.
Annals of diagnostic pathology (Impact Factor: 1.11). 05/2009; 13(2):114-8. DOI: 10.1016/j.anndiagpath.2007.06.009
Source: PubMed

ABSTRACT Giant cell tumor of the salivary gland is extremely rare, with only 15 cases published in the English literature. The tumor characteristically contains a mixture of multinucleated giant cells, resembling osteoclasts of bone, and neoplastic mononuclear cells. In about half of the reported cases, there is an associated carcinomatous component. We are reporting an additional case of giant cell tumor of the parotid gland that was initially misinterpreted as an extraosseous osteosarcoma in the biopsy specimen. The histologic and immunohistochemical findings as well as a review of the literature with discussion of the histogenesis of this unusual neoplasm are presented.

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    • "Primary GCTPs were first described by Eusebi et al in 1984 (4), however, due to their rarity, there is an absence of literature that has analysed GCTP and all published material has been case reports. A summary of fifteen case reports, located using PubMed in a search of data up to May 2012, are presented in Table I(4–13). The most common clinical presentation of a GCTP was a non-tender, growing mass over the preauricular area followed by swelling of the parotid gland. "
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