Psychosis in children with velocardiofacial syndrome (22q11.2 deletion syndrome)

Department of Child and Adolescent Psychiatry, Children's Hospital of Philadelphia, 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA.
Current Psychiatry Reports (Impact Factor: 3.24). 05/2009; 11(2):99-105. DOI: 10.1007/s11920-009-0016-y
Source: PubMed


Velocardiofacial syndrome, now known as 22q11.2 deletion syndrome (22qDS), is estimated to affect more than 700 children born in the United States each year. Some clinical studies have found increased rates of schizophrenia in adults with 22qDS. However, these studies have been limited by small sample size and possible ascertainment bias. The psychiatric disorders most commonly reported in children and adolescents with 22qDS have been attention-deficit/hyperactivity disorder, oppositional defiant disorder, anxiety disorders, and major depression. Psychotic symptoms have been observed in 14% to 28% of children with 22qDS, but their clinical significance remains uncertain. A 5-year follow-up study of 22qDS children who reported psychotic symptoms at baseline found they had an increased risk for a subsequent psychotic disorder. Thus, a broad differential diagnosis should be considered when 22qDS children present with psychotic symptoms. Longitudinal studies are needed to better understand the full extent of the psychopathology associated with 22qDS.

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    • "deletion but has also been reported in humans as a consequence of prenatal ethanol exposure [38]. Individuals with DiGeorge syndrome and FASD also share a substantially increased incidence of depression and psychotic disorders [39], [40]. Particularly notable are findings relative to schizophrenia, which is common in DiGeorge syndrome and also occurs as part of FASD [39], [41]. "
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