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Available from: José Leopoldo Ferreira Antunes, Oct 06, 2015
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    • "the biologic factors, may interfere in dental caries prevalence , which affects more extensively and more seriously disadvantaged groups, disclosing a scenario of inequity in the distribution of the disease [Narvai et al., 2006]. Alterations in the immune response to cariogenic bacteria may also be related to dental caries [Yildiz et al., 2009]. "
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    ABSTRACT: The purpose of this study was to evaluate the association between the frequencies of DR and DQ HLA class II alleles and the prevalence of dental caries in Brazilian adolescents. The study sample consisted of 164 adolescents aged 15- 19 years. For the assessment of caries experience the DMFT index was used, according to World Health Organization criteria. DNA samples of the adolescents were extracted from oral mucosa cells. The amplification of the alleles HLA-DR and HLA-DQ was carried out by polymerase chain reaction with sequence-specific primers (PCR-SSP). The products of PCR-SSP were electrophoresed and analyzed in agarose gel. Statistical analysis was performed using simple and multiple logistic regression to test the association between the adolescents' caries experience and the presence of HLA-DR and -DQ alleles. Sociodemographic covariates were included in the model. The significance level for all analyses was p < 0.05. The prevalence of caries was 60.4% and the mean DMFT was 2.41 ± 2.53. Adolescents positive for HLA-DQ2 allele were less likely to have dental caries than their counterparts who were negative for this allele (OR = 0.33, CI 0.16-0.66), and those whose mothers presented low levels of education were 2.01 (CI 1.02-3.97) times more likely to have dental caries. There was no statistical difference between HLA-DR4, -DQ4, -DQ5, -DQ6 and dental caries. Our data provide evidence that genes within the MHC, especially the DQ2 group, may influence susceptibility to dental caries in Brazilian adolescents.
    Caries Research 08/2012; 46(6):530-535. DOI:10.1159/000341188 · 2.28 Impact Factor
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    ABSTRACT: Key-words Este estudo determinou a prevalência e gravidade de cárie em crianças de 18-36 meses e 5 anos cadastradas no Programa Saúde da Família do Distrito Sanitário IV/Recife, em 2006. Estimou-se uma amostra probabilística de 1500 crianças: 900 de 18-36 meses e 600 de 5 anos, calculada com 27% e 65 % de prevalência e 5% e 6,5% de erro, respectivamente e grau de confiança de 95%. O efeito de desenho foi 1. Seguiram-se padronizações da OMS e Ministério da Saúde. Foram examinadas 1113 crianças significando uma taxa de resposta de 74,2%. A prevalência e IC 95% foram: 26,9% aos 18-36 meses e 60,6% aos 5 anos. O índice ceo-d foi de 0,98 e 2,85, respectiva- mente e o componente cariado predominou. Aos 18-36 meses 21 % das crianças concentraram em média entre 2 a 19 dentes com cárie e aos 5 anos 25% delas possuíam ceo-d entre 5 a 14. Acometimento precoce, altas prevalências e a polarização da cárie observada indicam necessida- de de intervenções populacionais e de saúde bucal integrais priorizando os grupos infantis com maiores necessidades e riscos. Cárie dentária. Pré-escolares. Polarização.
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    ABSTRACT: In most Brazilian cities, oral health is still a challenge for the Brazilian Health System (SUS). The aim of this study was to analyze the prevalence of dental caries (DMFT index), the dif- ferences with regard to gender and geographic lo- calization, Significant Caries Index and the per- centages of caries-free adolescents in Itaí-SP - Brazil, in 2006. The methodology used was in agree- ment with the criteria established by the WHO. The sample was composed of 178 teen-agers, cor- responding to 46% of the 12-years-old registered in the schools of the city. One single examiner per- formed the examination. The Kappa test method was used with an agreement rater of 0.95. The DMTF index was of 2.45, SiC of 5.08 and 30% of the adolescents were caries-free. It was observed that 70% of caries cases were concentrated in 34% of the adolescents. The data obtained showed a polarization of dental caries in 12-years-old ado- lescents, but this polarization was not uniform. The problems are concentrated in a small portion of the population.
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