Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: The JACC Study. Sleep, 32, 259-301

Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Sleep (Impact Factor: 4.59). 04/2009; 32(3):295-301.
Source: PubMed


To examine sex-specific associations between sleep duration and mortality from cardiovascular disease and other causes.
Cohort study.
Community-based study.
A total of 98,634 subjects (41,489 men and 57,145 women) aged 40 to 79 years from 1988 to 1990 and were followed until 2003.
During a median follow-up of 14.3 years, there were 1964 deaths (men and women: 1038 and 926) from stroke, 881 (508 and 373) from coronary heart disease, 4287 (2297 and 1990) from cardiovascular disease, 5465 (3432 and 2033) from cancer, and 14,540 (8548 and 5992) from all causes. Compared with a sleep duration of 7 hours, sleep duration of 4 hours or less was associated with increased mortality from coronary heart disease for women and noncardiovascular disease/noncancer and all causes in both sexes. The respective multivariable hazard ratios were 2.32 (1.19-4.50) for coronary heart disease in women, 1.49 (1.02-2.18) and 1.47 (1.01-2.15) for noncardiovascular disease/noncancer, and 1.29 (1.02-1.64) and 1.28 (1.03-1.60) for all causes in men and women, respectively. Long sleep duration of 10 hours or longer was associated with 1.5- to 2-fold increased mortality from total and ischemic stroke, total cardiovascular disease, noncardiovascular disease/noncancer, and all causes for men and women, compared with 7 hours of sleep in both sexes. There was no association between sleep duration and cancer mortality in either sex.
Both short and long sleep duration were associated with increased mortality from cardiovascular disease, noncardiovascular disease/noncancer, and all causes for both sexes, yielding a U-shaped relationship with total mortality with a nadir at 7 hours of sleep.

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Available from: Satoyo Ikehara, Sep 15, 2015
    • "Less than 5 hr " were categorized as having " sleep deprivation " , following the cutoff used in the previous study of sleeping hours and cardiovascular mortality [Ayas et al., 2003; Patel et al., 2004; Ferrie et al., 2007; Ikehara et al., 2009]. "
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    ABSTRACT: Evidence on the causal relationship between working overtime and the risk of coronary heart disease is limited. We surveyed 2355 workers in Japan and conducted propensity-matched logistic regression analysis, using propensity-matched 438 pairs, to evaluate the associations between working overtime (more than 50 hr per week) and coronary risk factors: physical inactivity, cigarette smoking, sleep deprivation (<5 hr/day), psychological stress, overweight/obesity, and excessive alcohol consumption. The exposure and outcomes were self-reported. Among 2355 workers, 476 participants worked overtime. Propensity-matched analysis revealed that the associations between working overtime and sleep deprivation (odds ratios (OR) and 95% confidence intervals: 2.33, 1.39-3.88) and high stress (2.13, 1.60-2.82). The associations between working overtime and physical inactivity, current smoking, and overweight/obesity were not statistically significant. Excessive alcohol consumption was inversely associated with working overtime. Working overtime was positively associated with two coronary risk factors: sleep deprivation and increased psychological stress. Am. J. Ind. Med. 58:229-237, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    American Journal of Industrial Medicine 02/2015; 58(2):229-37. DOI:10.1002/ajim.22409 · 1.74 Impact Factor
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    • "The study performed among 104,010 Japanese people aged from 40 to 79 years showed that sleep duration was a predictor of all-cause mortality among men and women (hazard ratios were slightly higher among females), but finally, in fully adjusted model, relation between short sleep duration and mortality was observed only among women (Tamakoshi and Ohno 2004). A later report of the Japanese cohort study showed a U-shaped relationship between sleep duration and all-cause mortality for both genders (Ikehara 2009). In one large study performed among people aged 30 and over in the USA, the results for males and females were also similar (Kripke et al. 2002), and the most recent critical review published by Kurina et al. (2013) has shown a lack of consistent differences between genders with regard to the association between sleep duration and mortality. "
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    European Journal of Ageing 06/2014; 12(2). DOI:10.1007/s10433-014-0318-8 · 1.27 Impact Factor
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    • "In recent years, there has been growing evidence of a relationship between habitual sleep and the risk of mortality from all-causes and cardiovascular diseases (CVDs) (1–3). Most of these studies focused on nighttime sleep duration (4, 5); the implications of daytime napping are poorly understood. A long-established practice in Mediterranean areas, daytime napping, namely siesta, is often linked with good health through a postulated “stress relief” mechanism (6). "
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    ABSTRACT: Epidemiologic studies have reported conflicting results on the relationship between daytime napping and mortality risk, and there are few data on the potential association in the British population. We investigated the associations between daytime napping and all-cause or cause-specific mortality in the European Prospective Investigation Into Cancer-Norfolk study, a British population-based cohort study. Among the 16,374 men and women who answered questions on napping habits between 1998 and 2000, a total of 3,251 died during the 13-year follow-up. Daytime napping was associated with an increased risk of all-cause mortality (for napping less than 1 hour per day on average, hazard ratio = 1.14, 95% confidence interval: 1.02, 1.27; for napping 1 hour or longer per day on average, hazard ratio = 1.32, 95% confidence interval: 1.04, 1.68), independent of age, sex, social class, educational level, marital status, employment status, body mass index, physical activity level, smoking status, alcohol intake, depression, self-reported general health, use of hypnotic drugs or other medications, time spent in bed at night, and presence of preexisting health conditions. This association was more pronounced for death from respiratory diseases (for napping less than 1 hour, hazard ratio = 1.40, 95% confidence interval: 0.95, 2.05; for napping 1 hour or more, hazard ratio = 2.56, 95% confidence interval: 1.34, 4.86) and in individuals 65 years of age or younger. Excessive daytime napping might be a useful marker of underlying health risk, particularly of respiratory problems, especially among those 65 years of age or younger. Further research is required to clarify the nature of the observed association.
    American journal of epidemiology 03/2014; 179(9). DOI:10.1093/aje/kwu036 · 5.23 Impact Factor
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