Case report of a sarcoma botryoides of the uterine cervix in fertile age and literature review

Department of Obstetrics and Gynecology, Second University of Naples, Via Palasciano, AORN Sant'Anna e S. Sebastiano, 81100 Caserta, Italy.
Archives of Gynecology (Impact Factor: 1.36). 04/2009; 280(5):863-6. DOI: 10.1007/s00404-009-1022-3
Source: PubMed


The sarcoma botryoides of the cervix uteri occurs very rarely in fertile women.
Here is a case of a 35-year-old fertile woman, who developed a sarcoma botryoides of the cervix uteri. The diagnosis required clinical examination, ecography, NMR, CT scan and a pathological examination of the surgical sample. Radical surgery and chemotherapy was performed. The patients is still living after more than 1 year after treatment.
Although the combined modality approach has given, if not constant, acceptable outcomes, a larger investigation on all the cases of sarcoma botryoides of the cervix uteri is expected.

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    • "At this localization, the tumor arises from the cervical mucosal epithelium or the middle tunica, and usually appears as a cervical polyp protruding out the external orifice. The tumor has a fast growth pattern, mainly spreading to the lungs and liver by blood circulation [7]. The etiology and specific risk factors are not known [6]. "
    Taiwanese Journal of Obstetrics and Gynecology 09/2014; 53(3):423–425. DOI:10.1016/j.tjog.2013.10.042 · 0.99 Impact Factor
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    ABSTRACT: Embryonal rhabdomyosarcoma (RMS) of the female genital tract usually occurs in the vagina during childhood. The uterine cervix as a primary site is rare, but is more frequent until the second decade of life. It usually has a good prognosis and the treatment is based on multidrug chemotherapy, radiotherapy and surgery. RMS accounts for <5% of all adult soft tissue sarcomas. Previous reports that included all primary sites showed a poorer five-year disease specific survival for adults with RMS when compared to the pediatric population. This difference has been attributed to a higher proportion of adverse prognostic clinical and pathological factors, and to inadequate treatment given to adults with RMS. A total of 115 patients with cervical embryonal RMS have previously been described; however, only 10 cases were reported in women older than 40 years. We present a 47-year-old woman treated with radical hysterectomy followed by adjuvant chemotherapy and review the current literature.
    Journal of Obstetrics and Gynaecology Research 03/2011; 37(7):940-6. DOI:10.1111/j.1447-0756.2010.01449.x · 0.93 Impact Factor
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    ABSTRACT: The association of a uterine sarcoma botryoides of the adolescence with a primitive neuroectodermal tumor is reported in a 12-year-old patient who presented with abnormal vaginal bleeding that occurred after passing per vaginam a polypoid mass. The sarcoma botryoides of the adolescence exhibited foci of cartilage and a central area of primitive neuroectodermal tumor with a trabecular, adamantiform histology and prominent angiogenesis. Primitive neuroectodermal tumor was positive for vimentin, synaptophysin, neuron-specific enolase, CD99, and SOX2 and negative for both the FLI-1 fusion protein and the rearrangement of ESWR1 gene. The neoplasm exhibited a nonaggressive behavior similar to sarcoma botryoides of the adolescence, being alive and well 3 y after its presentation. This is possibly related to its polypoid nature and the absence of invasive features at its uterine insertion level. A conservative approach without further resection and chemotherapy was indicated taking into account the patient's age.
    International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists 05/2012; 31(4):387-9. DOI:10.1097/PGP.0b013e31823ff3e6 · 1.67 Impact Factor
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