Fine needle aspiration cytology of inflammatory breast lesions.
ABSTRACT To study the characteristics of inflammatory breast aspirate by Fine Needle Aspiration, performed by pathologist.
Inflammatory breast aspirates reported at two hospitals in Taif area (King Abdul Aziz Specialist Hospital and Al Hada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia (KSA) from January 2000 till September 2007 were reviewed. The cytopathology reports, slides, clinical information, microbiology culture results, Tuberculosis; Polymerase Chain Reaction (TB; PCR) and histology were reviewed. The aspirates were identified as inflammatory based on presence of inflammatory cells and/or granulomas with occasional benign ductal epithelial cells. Cases of inflammatory carcinoma or duct ectasia were excluded.
Forty-nine cases of inflammatory breast aspirates were included in the study. The aspirates were categorized into: Acute mastitis/Abscess 13 (26.5%), Granulomatous Mastitis 15 (30.6%), Fat Necrosis / Organized Haematoma 8 (16.4%) and Inflammation, not otherwise specified (NOS) 13 (26.5%), based on morphologic criteria combined with clinical impression. The Granulomatous Mastitis cases were subcategorized into Idiopathic and Infection related which included Brucellosis, Tuberculosis, and fungal mastitis.
FNA of inflammatory breast lesions is a useful tool if performed by a pathologist and combined with further workup including microbiologic culture correlation. It helps in management and treatment of the patient and avoiding unnecessary surgery.
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ABSTRACT: Various types of lesion from inflammation to carcinoma can affect breast. Some lesions are common in young females while others in elderly age group. Early presentation and prompt diagnosis is essential to relieve anxiety of non-neoplastic conditions, and in case of carcinoma, it can save the patient from metastases. Many cases related to breast lesions from the region are reported in the surgery clinics of this institute and various breast diseases are being managed in the clinical departments. Analysis of pattern and prevalence will be a valuable guideline for clinicians of this location to compare with that of others. In the retrospective clinical study during 9 years period, the cases of breast lesions and lumps underwent fine needle aspiration cytology. Pap staining was done in alcohol fixed smears. The doubtful cases 65 were diagnosed through histopathological examinations by conventional method of fixation, processing and staining with routine hematoxylin and eosin. The cases with undetermined and inconclusive material were excluded from the study. In the study of total 243 cases, inflammatory conditions 22.6%, fibrocystic change 41.2%, fibroadenoma 21.8%, other benign breast disease 4.5%, gynaecomastia 2.5% and carcinoma 7.4% were detected. Fibrocystic change was the commonest lesion in this study with 33 years as the average age of presentation. However, malignancy was detected above 40 years of age.Asian Pacific journal of cancer prevention: APJCP 01/2010; 11(4):855-8. · 2.51 Impact Factor
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ABSTRACT: Background. A study was designed to see the role of fine needle aspiration cytology (FNAC) in palpable breast lumps. Materials and Methods. Four hundred and twenty five (425) patients came to the Department of Pathology King Edward Medical University, Lahore in four years for FNAC of their palpable breast masses from June 2006 to June 2010. FNAC diagnosis was compared with histological diagnosis to see the accuracy of fine needle aspiration cytology for neoplastic lesions. Results. There were 271/425 benign, 120/425 malignant, and 32/425 suspicious smears. Inadequate samples were repeated twice or thrice, and the degree of success was improved with consecutive repeating approaches. The frequency of inadequacy declined from 86 to 18, and 2 for first, second and third attempts, respectively. The number of repeats increased the diagnostic accuracy of aspirates which is statistically significant (P = .000). Invasive ductal carcinoma was the most commonly reported lesion with maximum incidence in the 4th, 5th, and 6th decades followed by invasive lobular carcinoma and other malignant lesions. The sensitivity, specificity, accuracy, negative predictive value, and the positive predictive value of FNAC was 98%, 100%, 98%, 100%, and 97%, respectively. Conclusion. FNAC serves as a rapid, economical, and reliable tool for the diagnosis of palpable breast lesions because the cytopathological examination of these lesions before operation or treatment serves as an important diagnostic modality.06/2011; 2011:689521. DOI:10.4061/2011/689521
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ABSTRACT: We report a case of primary actinomycosis of breast diagnosed by fine needle aspiration cytology (FNAC) in a postmenopausal lady who presented with a clinical impression of malignancy. Resolution of infection while conserving the breast was achieved by timely diagnosis and effective antibiotic therapy. The literature reports that primary actinomycosis of the breast is very rare after menopause, with only very few cases found after extensive search. It is imperative that this condition should be considered in the differential diagnosis of malignancy. The effectiveness of cell block sections in the final diagnosis is also highlighted.Journal of Cytology 07/2012; 29(3):197-9. DOI:10.4103/0970-9371.101173 · 0.41 Impact Factor