Sixty-one years of pancreatic cancer in Denmark from 1943 to 2003: a nationwide study.
ABSTRACT We report the incidence rates of pancreatic cancer in Denmark during 61 years of data registration, from 1943 to 2003.
On the basis of reports in the nationwide, population-based Danish Cancer Registry, we calculated age-standardized, period-specific incidence rates of pancreatic cancer.
A total of 32,654 incident cases of pancreatic cancer were evaluated (male-female ratio, 1.4). The age-standardized incidence rate of pancreatic cancer increased steadily in the beginning of the study period from 3.75/100,000 person-years in 1943 to 1947 to the maximum of 9.96/100,000 person-years in 1968 to 1972 among men and from 2.95 in 1943 to 1947 to the maximum of 7.04 in 1978 to 1982 among women. The incidence rates declined between 1968 to 1972 and 1988 to 1992 for men and between 1978 to 1982 and 2003 for women. Most tumors were located in the exocrine pancreas, and most were adenocarcinomas. More than 40% were located in the head of the pancreas; 14% were localized, 21% were regionally spread, and 36% were metastatic at the time of diagnosis. During the period 1978 to 2003, the percentages of histologically or cytologically verified adenocarcinomas remained relatively steady, approximately 30%.
The incidence rate of pancreatic cancer increased at the beginning of the 61 years of registration and declined slightly thereafter.
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ABSTRACT: Background / Purpose: Pancreatic adenocarcinoma initially presenting with a large osteoblastic lesion of the pelvis is uncommon. Two patients presented with large boney masses found to be metastatic pancreatic adenocarcinoma. Main conclusion: The important aspect of this poster lies in the necessity to biopsy suspicious lesions in order to make an accurate diagnosis to assure that appropriate treatment is obtained.Journal of Clinical Oncology 10/2010; 28(29):e545-9. · 18.04 Impact Factor
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ABSTRACT: Evaluation of incidence, treatment, and survival trends after resection of pancreatic cancer at a national level. Using data on patient and tumor characteristics from the nationwide Netherlands Cancer Registry trends were analyzed for the period 1989-2008. A total of 30,025 patients diagnosed with pancreatic cancer were included. The incidence remained stable over the 20-year study period at approximately 9 per 100,000 inhabitants. Resection rates increased from 8% in 1989 to 12% in 2008, adjuvant chemotherapy rates increased from 7% to 29%, and palliative chemotherapy rates increased from 5% to 19% (P < 0.0001 each). Relative survival proportions did not change over time; besides a minimal, nonsignificant increase at 3 months from 53% to 55%, these remained 34% at 6 months and 4.5% at 3 years. Among the patients undergoing tumor resection, relative survival increased from 82% to 93% at 3 months and from 51% to 63% at 1 year after diagnosis. However, no improvement was seen after 3 years (23%). The increased short-term survival among patients who underwent resection probably reflects decreased postoperative mortality driven by ongoing centralization efforts. However, longer-term survival remained poor irrespective of the changes in management in the past decades.Pancreas 05/2012; 41(7):1063-6. · 2.95 Impact Factor
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