Effects of ceftazidime and ciprofloxacin on biofilm formation in Proteus mirabilis rods

Department of Microbiology, Nicolaus Copernicus University in Toruń, Collegium Medicum, Bydgoszcz, Poland.
The Journal of Antibiotics (Impact Factor: 1.73). 06/2013; 66(10). DOI: 10.1038/ja.2013.59
Source: PubMed


Proteus mirabilis rods are one of the most commonly isolated species of the Proteus genus from human infections, mainly those from the urinary tract and wounds. They are often related to biofilm structure formation. The bacterial cells of the biofilm are less susceptible to routinely used antimicrobials, making the treatment more difficult. The aim of this study was to evaluate quantitatively the influence of ceftazidime and ciprofloxacin on biofilm formation on the polyvinyl chloride surface by 42 P. mirabilis strains isolated from urine, purulence, wound swab and bedsore samples. It has been shown that ceftazidime and ciprofloxacin at concentrations equal to 1/4, 1/2 and 1 times their MIC values for particular Proteus spp. strains decrease their ability to form biofilms. Moreover, ciprofloxacin at concentrations equal to 1/4, 1/2 and 1 times their MIC values for particular P. mirabilis strains reduces biofilm formation more efficiently than ceftazidime at the corresponding concentration values.The Journal of Antibiotics advance online publication, 26 June 2013; doi:10.1038/ja.2013.59.

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