Current and future developments in intracoronary optical coherence tomography imaging
ABSTRACT Optical coherence tomography (OCT) has become a key intracoronary imaging modality able to traverse some of the limitations of angiography and intravascular ultrasound. In vivo imaging with high resolution (around 15 micrometres) has given unique insights into not only atherosclerotic plaque, but also to the understanding of tissue responses underlying stent implantation. Novel developments with faster OCT pullback speeds will further simplify the procedural requirements and eventually eliminate the need for proximal vessel balloon occlusion during image acquisition. This report explores the current and future developments in OCT technology that will see this unique imaging modality become a key player in both the clinical and research arena for the interventional cardiologist.
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ABSTRACT: Pathological understanding of arterial diseases is mainly attributable to histological observations based on conventional tissue staining protocols. The emerging development of nonlinear optical microscopy (NLOM), particularly in second-harmonic generation, two-photon excited fluorescence and coherent Raman scattering, provides a new venue to visualize pathological changes in the extracellular matrix caused by atherosclerosis progression. These techniques in general require minimal tissue preparation and offer rapid three-dimensional imaging. The capability of label-free microscopic imaging enables disease impact to be studied directly on the bulk artery tissue, thus minimally perturbing the sample. In this review, we look at recent progress in applications related to arterial disease imaging using various forms of NLOM.Biophysical Reviews 12/2012; DOI:10.1007/s12551-012-0077-8
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ABSTRACT: Modern measurement equipment delivers more detailed data and faster data with each generation. These data can be used for different applications, one of them is doing real time display. Instead of saving all data during the measurements and analyze it afterwards, the data is displayed in real time and only especially selected parts of the data are saved for further work. Moving the screening part of the analysis to the human brain and pattern recognition avoids the saving of vast amounts of data and massive calculation power on computers afterwards and it dramatically improves the level of interaction with the measurement systems. This work starts first with a short look to the question what OCT is and how data is acquired. The different possibilities of volume rendering are presented in their basic ideas. Graphics hardware and algorithms are presented and discussed. Last the results of measurements taken by the system will be presented and discussed.Proceedings of SPIE - The International Society for Optical Engineering 06/2009; DOI:10.1117/12.831785 · 0.20 Impact Factor
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ABSTRACT: Detection of stent struts imaged in vivo by optical coherence tomography (OCT) after percutaneous coronary interventions (PCI) and quantification of in-stent neointimal hyperplasia (NIH) are important. In this paper, we present a new computational method to facilitate the physician in this endeavor to assess and compare new (drug-eluting) stents. We developed a new algorithm for stent strut detection and utilized splines to reconstruct the lumen and stent boundaries which provide automatic measurements of NIH thickness, lumen and stent area. Our original approach is based on the detection of stent struts unique characteristics: bright reflection and shadow behind. Furthermore, we present for the first time to our knowledge a rotation correction method applied across OCT cross-section images for 3D reconstruction and visualization of reconstructed lumen and stent boundaries for further analysis in the longitudinal dimension of the coronary artery. Our experiments over OCT cross-sections taken from 7 patients presenting varying degrees of NIH after PCI illustrate a good agreement between the computer method and expert evaluations: Bland-Altmann analysis revealed a mean difference for lumen cross-section area of 0.11 +/- 0.70 mm2 and for the stent cross-section area of 0.10 +/- 1.28 mm2.