Article

Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation.

Department of Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Cancer Investigation (impact factor: 1.85). 04/2009; 27(6):624-35. DOI:10.1080/07357900802653472 pp.624-35
Source: PubMed

ABSTRACT The purpose of this study was to investigate the sensitizing effect of curcumin on cisplatin-induced apoptosis in non-small cell lung cancer (NSCLC) H460 cells. Curcumin was shown to induce superoxide anion generation, down-regulate anti-apoptotic Bcl-2 protein, and subsequently sensitize cells to cisplatin-induced apoptosis. Co-treatment of the cells with curcumin and cisplatin resulted in increased apoptosis and reversal of Bcl-2-mediated cisplatin resistance. The mechanism by which curcumin down-regulates Bcl-2 and sensitizes cells to cisplatin-induced apoptosis involves proteasomal degradation of Bcl-2. These findings indicate a novel pathway for curcumin regulation of Bcl-2, which could benefit the development of a cisplatin sensitizing agent.

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Keywords

Bcl-2
 
Bcl-2-mediated cisplatin resistance
 
cisplatin sensitizing agent
 
cisplatin-induced apoptosis
 
curcumin down-regulates Bcl-2
 
down-regulate anti-apoptotic Bcl-2 protein
 
induce superoxide anion generation
 
non-small cell lung cancer
 
novel pathway
 
proteasomal degradation
 
sensitizes cells
 
sensitizing effect