Article

Serum growth factors in asbestosis patients.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Biomarkers (impact factor: 2.21). 03/2009; 14(1):61-6. DOI:10.1080/13547500802676868 pp.61-6
Source: PubMed

ABSTRACT Various growth factors, including platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-beta, have been implicated in the pathogenesis of asbestos-induced disease. PDGF and TGF-beta levels were determined by enzyme-linked immunosorbent assays in the banked serum samples of a cohort of workers with asbestosis, and the relationships of the growth factor levels to the subsequent development of cancer and to the radiographic severity and progression of asbestosis in the cohort were examined. Serum levels of PDGF and TGF-beta were found to be unrelated to the development of cancer, and serum levels of PDGF were found to be unrelated to the severity and progression of asbestosis. However, serum levels of TGF-beta were found to be statistically significantly related to disease severity (p = 0.01), increasing approximately 2.4-fold from ILO radiographic category 0 to category 3, and they were marginally related to disease progression (p = 0.07), in multivariate analysis controlling for other contributory factors including cumulative asbestos exposure. This suggests that serum TGF-beta may be a useful biomarker for asbestos-induced fibrotic disease.

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Keywords

asbestos-induced disease
 
asbestos-induced fibrotic disease
 
asbestosis
 
banked serum samples
 
contributory factors
 
cumulative asbestos exposure
 
disease progression
 
disease severity
 
enzyme-linked immunosorbent assays
 
growth factor
 
growth factor levels
 
ILO radiographic category 0
 
multivariate analysis
 
platelet-derived growth factor
 
serum levels
 
serum TGF-beta
 
subsequent development
 
TGF-beta levels
 
useful biomarker
 
Various growth factors