Article
Relationships of self-reported physical activity domains with accelerometry recordings in French adults.
Department of Nutrition, Pitié-Salpétrière Hospital (AP-HP); Human Nutrition Research Center Ile-de-France (CRNH-IdF), University Pierre et Marie Curie-Paris, 75013 Paris, France.
European Journal of Epidemiology (impact factor:
4.71).
01/2009;
24(4):171-9.
DOI:10.1007/s10654-009-9329-8
pp.171-9
Source: PubMed
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Citations (0)
- Cited In (4)
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Article: Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
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ABSTRACT: Large-scale genome-wide association (GWA) studies have thus far identified 16 loci incontrovertibly associated with obesity-related traits in adults. We examined associations of variants in these loci with anthropometric traits in children and adolescents. Seventeen variants representing 16 obesity susceptibility loci were genotyped in 1,252 children (mean ± SD age 9.7 ± 0.4 years) and 790 adolescents (15.5 ± 0.5 years) from the European Youth Heart Study (EYHS). We tested for association of individual variants and a genetic predisposition score (GPS-17), calculated by summing the number of effect alleles, with anthropometric traits. For 13 variants, summary statistics for associations with BMI were meta-analyzed with previously reported data (N(total) = 13,071 children and adolescents). In EYHS, 15 variants showed associations or trends with anthropometric traits that were directionally consistent with earlier reports in adults. The meta-analysis showed directionally consistent associations with BMI for all 13 variants, of which 9 were significant (0.033-0.098 SD/allele; P < 0.05). The near-TMEM18 variant had the strongest effect (0.098 SD/allele P = 8.5 × 10(-11)). Effect sizes for BMI tended to be more pronounced in children and adolescents than reported earlier in adults for variants in or near SEC16B, TMEM18, and KCTD15, (0.028-0.035 SD/allele higher) and less pronounced for rs925946 in BDNF (0.028 SD/allele lower). Each additional effect allele in the GPS-17 was associated with an increase of 0.034 SD in BMI (P = 3.6 × 10(-5)), 0.039 SD, in sum of skinfolds (P = 1.7 × 10(-7)), and 0.022 SD in waist circumference (P = 1.7 × 10(-4)), which is comparable with reported results in adults (0.039 SD/allele for BMI and 0.033 SD/allele for waist circumference). Most obesity susceptibility loci identified by GWA studies in adults are already associated with anthropometric traits in children/adolescents. Whereas the association of some variants may differ with age, the cumulative effect size is similar.Diabetes 11/2010; 59(11):2980-8. · 8.29 Impact Factor -
Article: New studies, technology, and the progress of epidemiology.
European Journal of Epidemiology 12/2010; 25(12):851-4. · 4.71 Impact Factor -
Article: The Rotterdam Study: 2012 objectives and design update.
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ABSTRACT: The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over a 1,000 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.European Journal of Epidemiology 08/2011; 26(8):657-86. · 4.71 Impact Factor
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Keywords
accelerometry sedentary time
detailed instrument
frequent non-occupational non-leisure PA
individuals partition
leisure-time PA
low habitual PA levels
lowest tertile
Modifiable Activity Questionnaire
non-occupational non-leisure PA
non-occupational non-leisure"
northern France
PA score
screening questionnaire
sedentary occupations
sedentary time
self-reported physical activity
Spearman correlation coefficients
total activity
total PA energy expenditure
women