Quantitative assessment of allergic shiners in children with allergic rhinitis
ABSTRACT The knowledge on allergic shiners is extremely limited. A conceivable tool able to quantify allergic shiners has not been established.
We sought to determine the significance and changeability of allergic shiners through our newly developed computerized method.
We developed a novel computerized method to measure allergic shiners and enrolled a cohort of children with or without allergic rhinitis. Children with allergic rhinitis were prospectively assessed. A standardized digital photograph was taken during each visit, and a modified Pediatric Rhinoconjunctivitis Quality of Life Questionnaire was completed. Subject global assessment for nose symptoms and subject global assessment for eye symptoms (SGAE) were self-recorded daily.
We included 126 children with allergic rhinitis and 123 healthy control subjects. One hundred three (82%) participants with allergic rhinitis completed at least 4 prospective assessments. Shiners were darker (P < .001) and larger (P < .001) in children with allergic rhinitis. Darkness and sizes of allergic shiners were paradoxically inversely correlated (P = .02). Darkness of allergic shiners positively correlated with the duration of allergic rhinitis, practical problem scores, and SGAE values (P = .02, P = .004, and P = .002, respectively), but sizes of allergic shiners did not. Shiners were found to be darker in children with scores of eye symptoms of greater than 6, scores of practical problems of greater than 5, and SGAE values of greater than 0 (P = .02, P < .001, and P = .003, respectively), whereas shiners were larger in children with scores of other symptoms of greater than 9 and activity limitations of greater than 4 (P = .02 and P = .002, respectively).
Computer-analyzed allergic shiners correlate with the chronicity and severity of allergic rhinitis.
Article: How allergic are "allergic shiners"?The Journal of allergy and clinical immunology 10/2009; 125(1):276; author reply 276. DOI:10.1016/j.jaci.2009.08.019 · 11.25 Impact Factor
Article: Reply.The Journal of allergy and clinical immunology 10/2009; DOI:10.1016/j.jaci.2009.08.022 · 11.25 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The purpose of this review is to highlight recently published important articles on upper airway diseases and immunotherapy. We review articles on rhinitis, sinusitis, conjunctivitis, and immunotherapy. New insights into epidemiology, pathophysiology, diagnosis, and therapy are described for each of the above diseases. Regarding immunotherapy, we discuss numerous clinical trials on sublingual and subcutaneous immunotherapy, mechanisms of immunotherapy, safety, and use of modified allergens and biological agents for immunotherapy.The Journal of allergy and clinical immunology 02/2011; 127(2):342-50. DOI:10.1016/j.jaci.2010.11.049 · 11.25 Impact Factor