Evidence for Transformation of Fibroadenoma of the Breast to Malignant Phyllodes Tumor

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Applied immunohistochemistry & molecular morphology: AIMM / official publication of the Society for Applied Immunohistochemistry (Impact Factor: 2.01). 04/2009; 17(4):345-50. DOI: 10.1097/PAI.0b013e318194d992
Source: PubMed


Fibroadenoma (FA) and phyllodes tumor (PT) of the breast are biphasic tumors composed of variable proportions of epithelial and stromal cells. We identified a case of synchronous FA and PT in the same breast mass. Using laser capture microdissection, loss of heterozygosity analysis was performed on these components to gain potential insight into the histogenetic relationship between FA and PT. Genomic DNA was analyzed at 10 microsatellite loci by polymerase chain reaction. Both tumors showed allelic loss at D7S522. In addition, phylloid tumor showed allelic loss at TP53 and D22S264, not observed in FA. Our data suggest that FA and PT are clonally related and allelic loss at TP53 and D22S264 may be implicated in the progression of FA to phyllode tumor.

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Available from: Shaobo Zhang, Feb 11, 2015
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    • "In addition, phylloid tumor also show allelic loss at TP53 and D22S264, that is not observed in fibroadenoma, suggesting that these tumors are clonally related and allelic loss at TP53 and D22S264 may be implicated in the progression of FA to phyllode tumor [9]. The effort in distinguishing fibroadenoma from phyllodes tumour is worthwhile for the reason that fibroadenoma after diagnosis can be followed up but the phyllodes tumour should be excised with a margin of at least 1 cm of normal breast tissue. "
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