Why cellular stress suppresses adipogenesis in skeletal tissue, but is ineffective in adipose tissue: Control of mesenchymal cell differentiation via integrin binding sites in extracellular matrices

Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA. Electronic address: .
Matrix biology: journal of the International Society for Matrix Biology (Impact Factor: 5.07). 06/2013; 32(7). DOI: 10.1016/j.matbio.2013.06.001
Source: PubMed


This Perspective addresses one of the major puzzles of adipogenesis in adipose tissue, namely its resistance to cellular stress. It introduces a concept of "density" of integrin binding sites in extracellular matrix, proposes a cellular signaling explanation for the observed effects of matrix elasticity and of cell shape on mesenchymal stem cell differentiation, and discusses how specialized integrin binding sites in collagen IV - containing matrices guard two pivotal physiological and evolutionary processes: stress-resistant adipogenesis in adipose tissues and preservation of pluripotency of mesenchymal stem-like cells in their storage niches. Finally, it proposes strategies to suppress adipogenesis in adipose tissues.

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Available from: Bjorn R Olsen, Jan 04, 2014
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