Comparative Physical Properties of Hyaluronic Acid Dermal Fillers

Genzyme Corporation, Cambridge, Massachusetts 01701, USA.
Dermatologic Surgery (Impact Factor: 1.56). 03/2009; 35 Suppl 1(1):302-12. DOI: 10.1111/j.1524-4725.2008.01046.x
Source: PubMed

ABSTRACT Hyaluronic acid (HA) fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. HA fillers appear to be similar, but their physical characteristics can be quite different. These differences have the potential to affect the ability of the physician to provide the patient with a natural and enduring result.
The objective of this article is to discuss the key physical properties and methods used in characterizing dermal fillers. These methods were then used to analyze several well-known commercially available fillers.
Analytical methods were employed to generate data on the properties of various fillers. The measured physical properties were concentration, gel-to-fluid ratio, HA gel concentration, degree of HA modification, percentage of cross-linking, swelling, modulus, and particle size.
The results demonstrated that commercial fillers exhibit a wide variety of properties.
Combining the objective factors that influence filler performance with clinical experience will provide the patient with the optimal product for achieving the best cosmetic result. A careful review of these gel characteristics is essential in determining filler selection, performance, and patient expectations.

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    • "DiHA formed by the degradation of HA with chondroitinase AC. cross-linking efficiency in BDDE cross-linked HA hydrogels, based on the chromatographic separation of polysaccharides formed by mild hydrolysis in alkaline conditions, was reported (Guarise, Pavan, Pirrone, & Renier, 2012). Enzymatic treatment with hyaluronidase of HA hydrogels cross-linked with BDDE (Kablik et al., 2009) and divinylsulfone (Chang et al., 2007) into oligosaccharides prior to chromatographic separation has also been described. A disadvantage with mild hydrolysis and hyaluronidase treatment of HA is that the degradation product consists of a complex mixture of larger oligosaccharides (>tetrasaccharides) making it difficult for a detailed analysis of the cross-linked residues. "
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