Robert, J. & Ohta, Y. Comparative and developmental study of the immune system in Xenopus. Dev. Dyn. 238, 1249-1270

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Developmental Dynamics (Impact Factor: 2.67). 06/2009; 238(6):1249-70. DOI: 10.1002/dvdy.21891
Source: PubMed

ABSTRACT Xenopus laevis is the model of choice for evolutionary, comparative, and developmental studies of immunity, and invaluable research tools including MHC-defined clones, inbred strains, cell lines, and monoclonal antibodies are available for these studies. Recent efforts to use Silurana (Xenopus) tropicalis for genetic analyses have led to the sequencing of the whole genome. Ongoing genome mapping and mutagenesis studies will provide a new dimension to the study of immunity. Here we review what is known about the immune system of X. laevis integrated with available genomic information from S. tropicalis. This review provides compelling evidence for the high degree of similarity and evolutionary conservation between Xenopus and mammalian immune systems. We propose to build a powerful and innovative comparative biomedical model based on modern genetic technologies that takes take advantage of X. laevis and S. tropicalis, as well as the whole Xenopus genus. Developmental Dynamics 238:1249-1270, 2009. (c) 2009 Wiley-Liss, Inc.

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Available from: Jacques Robert, Aug 28, 2015
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    • "Xenopus has been and still is one of the top model systems for the study of fundamental questions related to development, immunology, toxicology, neurobiology, embryology and regenerative biology (Du Pasquier et al., 1989; Khokha, 2012; Robert and Ohta, 2009). More recently Xenopus has also been increasingly used as a model for understanding tumor biology, transplantation biology, self tolerance and autoimmunity [reviewed in (Edholm and Robert, 2013). "
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    • "Afterwards, as metamorphosis starts, lymphocyte function becomes severely impaired with a consequent downregulation of the adaptive immune response. Finally, adult frogs show efficient immune response and antigen recognition (Robert and Ohta, 2009). Although the adaptive immune response has been thoroughly characterized during Xenopus development , the immune and inflammatory responses after injury have not been well studied. "
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