Robert, J. & Ohta, Y. Comparative and developmental study of the immune system in Xenopus. Dev. Dyn. 238, 1249-1270

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Developmental Dynamics (Impact Factor: 2.38). 06/2009; 238(6):1249-70. DOI: 10.1002/dvdy.21891
Source: PubMed


Xenopus laevis is the model of choice for evolutionary, comparative, and developmental studies of immunity, and invaluable research tools including MHC-defined clones, inbred strains, cell lines, and monoclonal antibodies are available for these studies. Recent efforts to use Silurana (Xenopus) tropicalis for genetic analyses have led to the sequencing of the whole genome. Ongoing genome mapping and mutagenesis studies will provide a new dimension to the study of immunity. Here we review what is known about the immune system of X. laevis integrated with available genomic information from S. tropicalis. This review provides compelling evidence for the high degree of similarity and evolutionary conservation between Xenopus and mammalian immune systems. We propose to build a powerful and innovative comparative biomedical model based on modern genetic technologies that takes take advantage of X. laevis and S. tropicalis, as well as the whole Xenopus genus. Developmental Dynamics 238:1249-1270, 2009. (c) 2009 Wiley-Liss, Inc.

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    • "This reduction in infection rate may result from the interplay between virus load, which depends on the exposure/re-exposure scenario, and the development of the tadpole immune system over time. Over the course of the larval development, the potential immune response increases in strength, complexity and diversity as the initial innate components are gradually supplemented by the adaptive components of immunity (Robert & Ohta, 2009). In Xenopus, for example, the larvae gradually develop spleen B cells, Lymphopoiesis, lymphocytes and immunoglobulin from Gosner stages 20 to 35 with the maximal immunity reached around Gosner stages 34–35. "
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    • "Xenopus has been and still is one of the top model systems for the study of fundamental questions related to development, immunology, toxicology, neurobiology, embryology and regenerative biology (Du Pasquier et al., 1989; Khokha, 2012; Robert and Ohta, 2009). More recently Xenopus has also been increasingly used as a model for understanding tumor biology, transplantation biology, self tolerance and autoimmunity [reviewed in (Edholm and Robert, 2013). "
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