Article

Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones.

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran.
Molecular Diversity (impact factor: 3.15). 03/2009; 13(3):385-7. DOI:10.1007/s11030-009-9122-3 pp.385-7
Source: PubMed

ABSTRACT Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.

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Keywords

1,3-indandione
 
corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones
 
environmentally unfavorable solvents
 
good yields