Comparison of clinical characteristics between early and late patterns in hospitalized patients with ovarian hyperstimulation syndrome
ABSTRACT To clarify the differences in clinical characteristics between early and late ovarian hyperstimulation syndrome (OHSS).
Tertiary university hospital.
Ninety-four patients/cycles hospitalized for moderate-to-severe OHSS after controlled ovarian hyperstimulation (COH) for IVF/intracytoplasmic sperm injection (ICSI); early type (n = 69) and late type (n = 25).
The COH and pregnancy outcomes, preclinical and clinical miscarriage rate, and hospital courses.
Serum E(2) levels (4,955.5 +/- 3,268.5 pg/mL vs. 2,340.8 +/- 960.6 pg/mL) and the number of follicles > or =11 mm on day of hCG administration (15.9 +/- 6.0 vs. 13.0 +/- 4.0), and the number of oocytes retrieved (21.9 +/- 9.7 vs. 13.2 +/- 5.9) were significantly higher in the early OHSS group compared with the late OHSS group. Clinical pregnancy rate (PR) was significantly higher in the late OHSS group (23.6% [13/55] vs. 92.0% [23/25]). There were no significant differences in multiple PR and disease severity between the two groups.
Early OHSS is associated with excessive ovarian response to gonadotropin stimulation, whereas late OHSS is closely associated with conception cycle. Our findings do not support that late OHSS is more severe and closely associated with multiple pregnancies compared with early OHSS.
Conference Paper: Hybrid position/Force control of multi-arm cooperating robots[Show abstract] [Hide abstract]
ABSTRACT: This paper extends the theory of hybrid position/force control to the case of multiarm cooperating robots. Cooperation between n robot arms is achieved by controlling each arm such that the burden of actuation is shared between the arms in a non-conflicting way as they control the position of and force on a designated point on an object. The object which may or may not be in contact with a rigid environment, is assumed to be held rigidly by n robot end-effectors. Natural and artificial position and force constraints are defined for a point on the object and two selection matrices are obtained to control the arms. The position control loops are designed based on each manipulator's Cartesian space dynamic equations. In the position control subspace, a feature is provided which allows the robot arms to exert additional forces/torques to achieve compression, tension, or torsion in the object without affecting the execution of the motion trajectories. In the force control subspace, a method is introduced to minimize the total force/torque magnitude square while realizing the net desired force/ torque on the environment.Robotics and Automation. Proceedings. 1986 IEEE International Conference on; 05/1986
Conference Paper: Arcing resistance of high fire point dielectric liquids[Show abstract] [Hide abstract]
ABSTRACT: High fire point (HFP) dielectric liquids have been in use since the demise of Askarels (PCB/TCB) in the mid-1970s. Having fire points of at least 300°C, their main application has been in the role of power transformer impregnants particularly in units located in, on, or near buildings. This study was aimed at evaluating the suitability of such liquids for application in arcing environments. At present, most HFP liquids are produced from one of three different chemical bases. These are: (a) polyol ester; (b) high molecular weight hydrocarbon (HMWH); and (c) dimethyl silicone. Samples of these liquids were evaluated in a typical oil switch primarily utilized in capacitor switching applications. Although not an HFP liquid, transformer oil was included in the test matrix to provide a base line to which the other liquids could be compared. Each liquid was exposed to 250 cycles of switching 8,000 volts at 50 amps (a duty well within the capability of the switch). The results show that both polyol-ester and high molecular weight hydrocarbons compare favorably to transformer oil in this application. However, the dielectric breakdown value of dimethyl silicone was so rapidly degraded that its use under such conditions requires considerable cautionElectrical Insulation, 1996., Conference Record of the 1996 IEEE International Symposium on; 07/1996
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ABSTRACT: Ovarian hyperstimulation syndrome (OHSS) is a complication of in vitro fertilization associated with physiological changes after hCG administration to induce final oocyte maturation. It presents as widespread increases in vascular permeability and, in rare cases, results in cycle cancellation, multi-organ dysfunction, and pregnancy termination. These physiological changes are due primarily to activation of the vascular endothelial growth factor (VEGF) system in response to exogenous human chorionic gonadotropin (hCG). An hCG antagonist (hCG-Ant) could attenuate these effects by competitively binding to the LH/CG receptor, thereby blocking LH activity in vivo. We expressed a form of hCG that lacks three of its four N-linked glycosylation sites and tested its efficacy as an antagonist. The hCG-Ant binds the LH receptor with an affinity similar to native hCG and inhibits cAMP response in vitro. In a rat model for ovarian stimulation, hCG-Ant dramatically reduces ovulation and steroid hormone production. In a well-established rat OHSS model, vascular permeability and vascular endothelial growth factor (VEGF) expression are dramatically reduced after hCG-Ant treatment. Finally, hCG-Ant does not appear to alter blastocyst development when given after hCG in mice. These studies demonstrate that removing specific glycosylation sites on native hCG can produce an hCG-Ant that is capable of binding without activating the LH receptor and blocking the actions of hCG. Thus hCG-Ant will be investigated as a potential therapy for OHSS.Endocrinology 06/2009; 150(8):3807-14. DOI:10.1210/en.2009-0107 · 4.64 Impact Factor