Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

Trudeau Institute, Saranac Lake, NY 12983, USA.
Immunity (Impact Factor: 21.56). 03/2009; 30(3):421-33. DOI: 10.1016/j.immuni.2009.01.006
Source: PubMed


Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We also demonstrated that cytokine-producing effector B cells were essential for effective immunity to H. polygyrus. Tumor necrosis factor alpha production by B cells was necessary for sustained Ab production, whereas interleukin 2 production by B cells was necessary for Th2 cell expansion and differentiation. These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses.

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Available from: Melissa R Makris, Feb 18, 2015
    • "Evidence of protective immunity against helminth parasites has been obtained from observations generated by passive transference of immune serum, purified IgG or monoclonal antibodies into naïve experimental animals (McCoy et al., 2008; Gurish et al., 2004; Blackwell and Else, 2001; Rajan et al., 2005; Marcet et al., 2002; Attallah et al., 1999; Inaba et al., 2003; Harris et al., 2006; Herbert et al., 2002; Ligas et al., 2003). However, it is important to note that not all studies have reported such a protective effect (Liu et al., 2010; Wojciechowski et al., 2009; Harrison et al., 2008), suggesting that the ability of antibodies to mediate protective immunity depends on the parasite species investigated. "
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