Association Between Age-Related Hearing Loss and Stroke in an Older Population

Department of Ophthalmology, Westmead Millennium Institute and Australian Health Policy Institute, Centre for Vision Research, University of Sydney, Westmead Hospital, Westmead, NSW, Australia.
Stroke (Impact Factor: 5.72). 02/2009; 40(4):1496-8. DOI: 10.1161/STROKEAHA.108.535682
Source: PubMed


Very few studies have investigated the association between hearing loss and stroke. A recent article in Stroke reported an increased incidence of stroke among patients with sudden hearing loss over a 5-year follow-up period. Our study aimed to explore this association among subjects with age-related hearing loss from a representative population. Further, we looked at the association between severity of hearing loss and risk of stroke in older persons, acknowledged as a limitation by the authors of the Stroke report.
The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss conducted during 1997 to 1999 and 2002 to 2004, among participants of the Blue Mountains Eye Study. Pure-tone air conduction hearing thresholds from 0.25 to 8.0 kHz were measured by audiologists. Hearing loss was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 dB HL in the better ear.
Persons with moderate to severe hearing loss had a significantly higher likelihood of reporting previous stroke (OR, 2.04; 95% CI, 1.20-3.49) after multivariable adjustment. However, moderate to severe hearing loss did not predict incident stroke after 5-year follow-up (OR, 1.14; 95% CI, 0.59-2.23).
We observed a strong cross-sectional association between stroke and moderate to severe hearing loss. However, age-related hearing loss did not increase risk of incident stroke in our cohort. Insufficient study power or differing underlying pathologies of sudden sensorineural hearing loss and typical age-related hearing loss may account for the discrepant findings between these studies.

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Available from: Bamini Gopinath, Jan 19, 2014
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    • "The prevalence of ARHL is expected to increase with aging population [7, 68–70]. Although many factors have been researched including environmental, hereditary, and medical factors [71] [72], the precise mechanism of ARHL is not yet understood. "
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    ABSTRACT: Reactive oxygen species (ROS) production is involved in several apoptotic and necrotic cell death pathways in auditory tissues. These pathways are the major causes of most types of sensorineural hearing loss, including age-related hearing loss, hereditary hearing loss, ototoxic drug-induced hearing loss, and noise-induced hearing loss. ROS production can be triggered by dysfunctional mitochondrial oxidative phosphorylation and increases or decreases in ROS-related enzymes. Although apoptotic cell death pathways are mostly activated by ROS production, there are other pathways involved in hearing loss that do not depend on ROS production. Further studies of other pathways, such as endoplasmic reticulum stress and necrotic cell death, are required.
    04/2015; 2015:1-7. DOI:10.1155/2015/617207
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    • "The prevalence of the ARHL is expected to increase as the elderly population grows [9, 13, 14]. It has been proposed that ARHL is associated with many factors, including environmental, medical, and hereditary factors [12, 15]. So far, no effective treatment has been found for this age-related disorder. "
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    ABSTRACT: Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells. ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants. In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.
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    • "), 중등도-심도 난청자의 이전 뇌졸중 보고의 비차비는 2.04(95% CI, 1.20-3.49)를 보였다 (Gopinath et al., 2009). 그러나 이 연구에서는 "
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    ABSTRACT: Hearing loss is a common health issue caused by aging, disease, noise, and genetic factors. Besides ear diseases, systemic diseases can be leading causes in hearing loss. This paper investigates the influence of systemic diseases on hearing loss by examining the relationship between hearing loss and representative kidney disease, diabetes mellitus, rheumatoid arthritis, arterial sclerosis, stroke, chronic obstructive pulmonary diseases, cataracts, hyperlipidemia and immune diseases such as systemic lupus erythematosus (SLE). In addition, hearing loss caused by aging, namely the influence of bone density and menopause in women on hearing loss, was reviewed.
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