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Selenium and vitamin E: Interesting biology and dashed hope

Affiliations of author: Glickman Urological and Kidney Institute, Center for Clinical & Translational Research, and Department of Surgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH.
CancerSpectrum Knowledge Environment (Impact Factor: 15.16). 03/2009; 101(5):283-5. DOI: 10.1093/jnci/djp009
Source: PubMed
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    • "However, their efficacy in vivo remains a matter of debate. Animal models have been widely used to test a number of antioxidant compounds, and though these studies have been relatively promising, clinical trials with antioxidant compounds have not always lived up to expectations (Schwedhelm et al., 2003; Kamat et al., 2008; Klein, 2009; Wojcik et al., 2010; Floyd et al., 2011). One reason why antioxidants have performed poorly in clinical trials might have to do with the fact that these compounds may only be effective in a narrow temporal window in relation to oxidative damage. "
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    Experimental gerontology 07/2012; 47(9):712-22. DOI:10.1016/j.exger.2012.06.016 · 3.53 Impact Factor
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    CancerSpectrum Knowledge Environment 09/2009; 101(19):1363-4; author reply 1364. DOI:10.1093/jnci/djp272 · 15.16 Impact Factor
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