Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

Mukogawa Women's University, Japan.
Advances in Experimental Medicine and Biology (Impact Factor: 1.96). 02/2009; 643:13-25. DOI: 10.1007/978-0-387-75681-3_2
Source: PubMed


The initial observation that taurine (T) prevented stroke in stroke-prone spontaneously hypertensive rats (SHRSP) led us to study the effects of T on cardiovascular diseases (CVD), as well as the epidemiological association of T and mortality rates, by using the data from WHO-coordinated Cardiovascular Disease and Alimentary Comparison Study, which covered 61 populations in 25 countries. In this study, 24 hour urine (24-U) samples were examined along with biomarkers of CVD risk. The mortality rate from ischemic heart disease (IHD), which was lowest among the Japanese compared to the populations of other developed countries, was positively related to total serum cholesterol (TC) and inversely related to 24-U taurine excretion (24-UT), as well as the n-3 fatty acid to total phospholipids ratio of the plasma membrane, both biomarkers of seafood intake. Analysis of 5 diet-related factors revealed that TC and BMI were positively associated with IHD mortality in both genders while Mg and T were negatively associated with IHD mortality. TC and sodium (Na) were negatively and positively associated with stroke mortality, respectively. 24-UT was negatively associated with stroke mortality. These five diet-related factors explained 61 and 49% of IHD and stroke variances in male, 63 and 36% of IHD and stroke variances in female, respectively.

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Available from: Longjian Liu, Oct 01, 2015
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    • "Hence, additional studies examining the therapeutic benefit (if any) of taurine in the treatment of diabetes and the metabolic syndrome are warranted. Based on the wide multi-center, cross-sectional World Health Organization investigation known as the CARDIAC study, an inverse relationship exists between cardiovascular mortality and dietary taurine intake, as monitored by urinary taurine levels (Yamori et al. 2001, 2009). The rationale for the study is that taurine exerts opposite actions on events that influence atherosclerosis, such as hypercholesterolemia , inflammation and oxidative stress (Murakami et al. 2010a, b, 2013). "
    Amino Acids 12/2013; 46(1). DOI:10.1007/s00726-013-1632-8 · 3.29 Impact Factor
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    • "Many reports indicate that taurine participates in the development of diabetes. Epidemiological study demonstrated that higher dietary intakes of taurine are associated with lower cardiovascular risks (Yamori et al. 2009). Similarly, plasma taurine concentrations are found to be low in patients with diabetes (Franconi et al. 1995; De Luca et al. 2001), thus suggesting that diabetes can be considered to be a taurine-deficient condition. "
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    ABSTRACT: Metabolic syndrome is characterized by the cluster of a number of metabolic abnormalities in the presence of underlying insulin resistance. The prevalence of metabolic syndrome has steadily increased in all populations worldwide. Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid that is involved in a variety of physiological functions. Clinical and experimental studies show that taurine intake may be beneficial in the prevention of metabolic syndrome including diabetes, obesity, dyslipidemia, and hypertension. This article reviews the effect of taurine on all of the components of metabolic syndrome. In addition, the possible mechanisms by which taurine prevents diabetes and metabolic syndrome are also discussed. Further study is needed to determine the role of taurine in the development of metabolic syndrome in humans, because there is presently limited clinical data available.
    Amino Acids 12/2012; 46(1). DOI:10.1007/s00726-012-1434-4 · 3.29 Impact Factor
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    • "Marine fish protein can also benefit the heart [NCEP Report 2001]. Recent studies provide little or no direct evidence about how fish proteins and amino acids taurine, methionine can prolong life or prevent or delay CAD events (Yamori et al. 2009). Today, it is open question. "
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    ABSTRACT: Recent recommendations of federal and regulatory agencies suggest revisit the claims of fish oils rich in omega-3 fatty acids and benefits in prevention of cardiovascular disease. We propose the importance of fish proteins in prevention of CVD to offer better opportunity of lowering blood pressure and coronary artery disease burden. Fish proteins are analyzed by protein electrophoresis after extraction from fish. The nutrition value of fish protein components are estimated and compared with recommended daily allowances (RDA). However, benefits of fish proteins remain less known due to poor knowledge of clinical outcomes, endpoint calibrations and their food value. The current status of fish dietary research and possibility of their use in coronary artery disease as cardioprotective food is presented if the fish protein intake may be better approach over omega fatty acids as reliable, relevant dietary recommendations for CVD in future.
    Dyslipidemia: Causes, Diagnosis and Treatment, 1 01/2012: chapter 4; Nova Publishers Company, NY., ISBN: 978-1-62100-917-7
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