Article

Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

Mukogawa Women's University, Japan.
Advances in Experimental Medicine and Biology (Impact Factor: 2.01). 02/2009; 643:13-25. DOI: 10.1007/978-0-387-75681-3_2
Source: PubMed

ABSTRACT The initial observation that taurine (T) prevented stroke in stroke-prone spontaneously hypertensive rats (SHRSP) led us to study the effects of T on cardiovascular diseases (CVD), as well as the epidemiological association of T and mortality rates, by using the data from WHO-coordinated Cardiovascular Disease and Alimentary Comparison Study, which covered 61 populations in 25 countries. In this study, 24 hour urine (24-U) samples were examined along with biomarkers of CVD risk. The mortality rate from ischemic heart disease (IHD), which was lowest among the Japanese compared to the populations of other developed countries, was positively related to total serum cholesterol (TC) and inversely related to 24-U taurine excretion (24-UT), as well as the n-3 fatty acid to total phospholipids ratio of the plasma membrane, both biomarkers of seafood intake. Analysis of 5 diet-related factors revealed that TC and BMI were positively associated with IHD mortality in both genders while Mg and T were negatively associated with IHD mortality. TC and sodium (Na) were negatively and positively associated with stroke mortality, respectively. 24-UT was negatively associated with stroke mortality. These five diet-related factors explained 61 and 49% of IHD and stroke variances in male, 63 and 36% of IHD and stroke variances in female, respectively.

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    • "Hence, additional studies examining the therapeutic benefit (if any) of taurine in the treatment of diabetes and the metabolic syndrome are warranted. Based on the wide multi-center, cross-sectional World Health Organization investigation known as the CARDIAC study, an inverse relationship exists between cardiovascular mortality and dietary taurine intake, as monitored by urinary taurine levels (Yamori et al. 2001, 2009). The rationale for the study is that taurine exerts opposite actions on events that influence atherosclerosis, such as hypercholesterolemia , inflammation and oxidative stress (Murakami et al. 2010a, b, 2013). "
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    • "Marine fish protein can also benefit the heart [NCEP Report 2001]. Recent studies provide little or no direct evidence about how fish proteins and amino acids taurine, methionine can prolong life or prevent or delay CAD events (Yamori et al. 2009). Today, it is open question. "
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    • "Recent studies suggest that amino acids may regulate blood pressure. The potential health benefits of taurine as a nutritional factor in reducing hypertension and cardiovascular disease have been discussed (Xu et al., 2010; Yamori et al., 2009) and dietary intake of vegetable proteins rich in glutamic acid is known to lower the incidence of essential hypertension (Stamler et al., 2009). Acute intravenous administrations of L-serine and glycine lowered blood pressure (BP) in normotensive rats and in vitro addition of L-serine evoked endothelium-dependent vasodilatation of third-order branches of rat superior mesenteric artery (MA) (Mishra et al., 2008a,b). "
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