Hyperbilirubinemia is the most common condition requiring evaluation and treatment in newborns. The clinical manifestation of hyperbilirubinemia-jaundice-occurs in 60% of normal newborns and nearly all preterm infants. Compared with conditions that require advanced pharmacologic and technologic treatment strategies, hyperbilirubinemia seems to be overshadowed and may lose the attention it deserves as a condition that has potentially devastating effects. Nurses must be vigilant when caring for babies with "just jaundice" by monitoring bilirubin levels, identifying infants at risk for developing severe hyperbilirubinemia, and implementing prescribed treatment effectively when indicated.
[Show abstract][Hide abstract] ABSTRACT: "Common" neonatal jaundice can lead to dangerous levels of hyperbilirubinemia, causing neurological damage and even death. This article outlines evidence-based assessment techniques, management guidelines, and treatments for neonatal hyperbilirubinemia, addressing complexities that have arisen with new technologies and research results. We also explicate the role of the nurse in both prevention and care of patients and families who are affected by hyperbilirubinemia and jaundice.
MCN. The American journal of maternal child nursing 11/2013; 38(6):377-82. DOI:10.1097/NMC.0b013e3182a1fb7a · 0.90 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Jaundice in term and near-term (35 to 37 week) infants is generally benign, however, concern has surfaced in recent years regarding reemergence of kernicterus in this patient population. An increasing number of litigation cases centering on kernicterus have arisen and increasingly apparent is the fact that otherwise healthy newborn infants may be at risk for this potentially devastating neurologic condition. The purpose of this article is to provide a review on hyperbilirubinemia in term and near-term infants. Historical perspective, brief review of bilirubin physiology, and etiologies of hyperbilirubinemia will be followed by a discussion of physiologic effects/clinical symptoms of elevated serum bilirubin levels, kernicterus, and potential sequale. Methods for evaluation, treatment, and prevention of significant hyperbilirubinemia will be included.
Newborn and Infant Nursing Reviews 12/2004; 4(4):191-200. DOI:10.1053/j.nainr.2004.09.001
[Show abstract][Hide abstract] ABSTRACT: Microglia constitute the brain's immunocompetent cells and are intricately implicated in numerous inflammatory processes included in neonatal brain injury. In addition, clearance of tissue debris by microglia is essential for tissue homeostasis and may have a neuroprotective outcome. Since unconjugated bilirubin (UCB) has been proven to induce astroglial immunological activation and neuronal cell death, we addressed the question of whether microglia acquires a reactive phenotype when challenged by UCB and intended to characterize this response.
Neurobiology of Disease 12/2010; 40(3):663-75. DOI:10.1016/j.nbd.2010.08.010 · 5.08 Impact Factor
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