Single site meta-analysis of 6% hydrogen peroxide whitening strip effectiveness and safety over 2 weeks
ABSTRACT This research evaluated efficacy and safety of 6% hydrogen peroxide whitening strips from a clinical trials database accumulated over a multi-year period at a single site.
The inclusive meta-analysis involved seven different randomized clinical trials at one dental school. Each study used 6% hydrogen peroxide whitening strips twice daily for 30min over a 2-week period. Common efficacy (digital images) and safety (examination and interview) methods were used across studies. Pooled subject-level data were analyzed using a general linear mixed model to determine overall response and effects of treatment duration on whitening.
The 148 treated subjects were 18-71 years old, with b* (yellowness) ranging from 12 to 22, and L* (lightness) ranging from 69 to 80. After 1-week strip use, the adjusted mean (S.E.) for Deltab* was -1.6 (0.08), differing significantly from baseline (p<0.0001). After 2 weeks, the adjusted mean (S.E.) for Deltab* was -2.3 (0.07), differing significantly from Week 1 (p<0.0001). The estimated correlation between Weeks 1 and 2 for Deltab* was 0.74. Study-to-study variation contributed less than 2% of Deltab* variability. Results were similar for DeltaL*, with Weeks 1 and 2 estimated means (S.E.) of 1.5 (0.13) and 2.0 (0.12). Occurrence of oral irritation (22%) and tooth sensitivity (20%) did not adversely affect whitening. Other side effects were unremarkable, and only 1 subject (0.7%) discontinued treatment early due to an adverse event.
The meta-analysis of multiple studies conducted at a single clinical site over several years establishes consistent, effective and safe vital bleaching with 6% hydrogen peroxide whitening strips.
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ABSTRACT: The demand for cosmetic dentistry, including teeth whitening, has increased in recent years. The home teeth whitening and in-office, are widely used in dental practice. The mechanism by which it works is by oxidation of the chromogenic existing tooth structure. This is an effective and minimally invasive procedure that achieves tooth lighten the color, however, may cause alterations in the enamel surface, such as a dental permeability increase. Another effect caused by this procedure is tooth sensitivity, being the most common side effect, up to 65% of individuals have had a secondary effect at least once during treatment. This sensitivity and gingival irritation caused by bleaching may vary depending on the patient and used bleaching product.Revista dental de Chile 02/2014; 104(1):14.
International Journal of Morphology 06/2010; 28(2):461-470. · 0.20 Impact Factor
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ABSTRACT: OBJECTIVES: This randomized, parallel group, single center clinical trial was conducted to evaluate the safety and compare the whitening efficacy for an extended wear of an experimental 9.5% H2O2 high-adhesion whitening strip, relative to a marketed 10% H2O2 control strip. METHODS: Twenty-nine eligible adult volunteers were randomly assigned to either a treatment series with an experimental 9.5% H2O2 high-adhesion whitening strip at home for two hours, once a day, for 8 days; or a marketed 10% H2O2 whitening strip for 30minutes, on a similar daily regimen. Tooth color/whitening progression was recorded under standardized lighting conditions at baseline, day 3, day 5, and day 9, via digital imaging. Outcomes were reported using the CIELAB system. Usage safety was also assessed at each follow-up visit. Whitening efficacy for each group was investigated using a paired-difference t-test. The treatment groups were compared among each other using the analysis of covariance, with the baseline value and age as the covariates. RESULTS: Both treatment groups demonstrated statistically significant mean color improvement from baseline for b* (yellowness) and L* (lightness) at each post-baseline visit. In addition, the 2-hour high-adhesion strips demonstrated significantly greater improvement in b* and L* relative to the 30-minute strip group at each follow-up visit. CONCLUSIONS: The 2-hour regimen for the 9.5% H2O2 high-adhesion whitening strip was more efficient for tooth whitening than the 30-minute regimen of 10% H2O2 whitening strip. Both treatments were well tolerated and the use of the test products during the study time frame was considered safe. CLINICAL RELEVANCE: Extending the daily wear time of whitening strips can improve the efficacy of the treatment and ultimately shorten the length of the treatment without any significant adverse effects.Journal of dentistry 12/2012; 41. DOI:10.1016/j.jdent.2012.11.019 · 2.84 Impact Factor