Cutaneous ulcer due to histoplasmosis and HIV infection
Department of Dermatology, Institute of Tropical Medicine of the Amazonas State, -, Brasilien.Der Hautarzt (Impact Factor: 0.56). 03/2009; 60(12):992-4. DOI: 10.1007/s00105-009-1711-7
A 33-year-old Brazilian man presented with a painful ulcer on the glabella region. The patient was HIV-positive. Diagnosis of histoplasmosis was established by histopathological examination. In Latin America, disseminated histoplasmosis frequently involves the skin of HIV-positive patients. When affecting the skin, the disease has a wide range of clinical presentations. Our case highlights the importance of including this disease in the differential diagnosis of cutaneous ulcers in HIV patients from areas endemic for histoplasmosis.
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ABSTRACT: We describe a case of a patient presenting with HIV and paracoccidioidomycosis co-infection. At the time of diagnosis total CD4+ T-cell count was 4 cells/mm3. Histopathology revealed tuberculoid granulomas, scarce CD4+ T cells, a moderate number of CD8+ cells and the absence of Foxp3+ cells. Most of the cutaneous lesions healed after two weeks of treatment with amphotericin B. After 14 months the patient is still under antiretroviral therapy and no clinical evidence of recurrence of the mycosis has been observed.Anais brasileiros de dermatologia 07/2011; 86(4 Suppl 1):S129-32. DOI:10.1590/S0365-05962011000700034 · 0.72 Impact Factor
Article: Histoplasmosis and AIDS co-infection[Show abstract] [Hide abstract]
ABSTRACT: This report concerns an AIDS patient presenting systemic and cutaneous manifestations of histoplasmosis. A histopathological and mycological examination of the skin lesion confirmed the diagnosis. In AIDS patients histoplasmosis arises mainly when the T-CD4+ cell count is less than 50 cells/mm3. In such cases, histoplasmosis can be severe and if left untreated can lead to death, as occurred with this patient.Anais brasileiros de dermatologia 10/2011; 86(5):1025-6. DOI:10.1590/S0365-05962011000500028 · 0.72 Impact Factor
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