Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan.

Isfahan University of Medical Scienses Radiology Isfahan, Iran.
Endokrynologia Polska (Impact Factor: 1.21). 60(1):14-9.
Source: PubMed

ABSTRACT Children's obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high rate of child obesity. Fatty liver is an abnormality related to metabolic syndrome, with higher prevalence in obese children according to some previous studies. This study investigates the presence of Sonographic Fatty Liver (SFL) in Iranian obese children in comparison with normal and overweight children.
This was a cross-sectional study on 962 randomly selected children between the ages of 6 to 18 years. The subjects were divided into three groups of normal, overweight and obese based on body mass index (BMI). A questionnaire including demographic and anthropometric characteristics was filled for each one. To detect the presence of SFL all the subjects underwent assessments with ultrasonography by radiologist who was not aware of their BMI. The incidence of SFL was determined based on the ultrasonographic diagnosis criteria.
The average age of the children in the study was 12.59 +/- 3.25 years. The mean of the liver span in the normal, overweight and obese groups were 111.36 +/- 18.73, 121.18 +/- 16.63 and 118.21 +/- 19.15 respectively. The prevalence of SFL in obese children was 54.4%, which was significantly higher than overweight (10.5%) and normal ones (1%). According to present results, there was no significant difference in prevalence of SFL between sexes.
The high rate of detected SFL in obese children in this study suggests that Iranian obese children are at risk of metabolic syndrome. Moreover, the WHO indicated Iran as one of the countries with high rate of obese children. Based on this information, we can conclude that the prevalence of metabolic syndrome and its related non-communicable diseases will be increasing future in . Therefore, it is necessary to develop some plan to control overweight problem including teaching healthy lifestyle in schools and kindergartens as well as mass media.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: Obesity is a global epidemic and its morbidities such as metabolic syndrome, insulin resistance, and fatty liver leads to a spectrum of psycho-social and medical consequences. Objectives: The objective of this study was to investigate the prevalence of fatty liver in obese Iranian children and its' association with metabolic syndrome and insulin resistance. Patients and Methods: 102 obese Iranian children, referred to pediatric clinics from March 2011 to March 2012, were enrolled in this cross-sectional study. All the patients were visited by a pediatric endocrinologist, a pediatric gastroenterologist and an expert radiologist in the evaluation of fatty liver grading. Results: The grade of fatty liver was higher in older children (P = 0.001). It was also more in taller and heavier children (P = 0.000). The more the BMI was, the more the fatty liver grade was (P = 0.002). Severity of fatty liver according to liver sonography in patient had a positive relationship with waist circumference, hip circumference, serum TG, serum FBS, serum fasting insulin, serum ALT, systolic blood pressure and HOMA index and had a negative correlation with the level of alkaline phosphatase. Severity of fatty liver also had a close relationship with the presence of acanthosis nigricans and HOMA index. Conclusions: Prevalence of fatty liver is high in our obese children. It was associated with criteria of metabolic syndrome and insulin resistance, so visceral fat may participate in the pathogenesis of the metabolic syndrome or merely serve as a marker of increased risk for the metabolic complications of obesity.
    05/2014; 16(5):e6656. DOI:10.5812/ircmj.6656
  • [Show abstract] [Hide abstract]
    ABSTRACT: Predictors of quantitative evaluation of hepatic steatosis and liver fat content (LFC) using clinical and laboratory variables available in the general practice in the obese children are poorly identified.
    Pediatric Obesity 06/2014; DOI:10.1111/ijpo.232 · 2.42 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is rapidly increasing in the Asia-Pacific and affects up to 30 % of the general population. In younger children, prevalence has been reported to be between 2.1 and 4.5 %. The prevalence of NAFLD increases with increasing age. NAFLD is more prevalent in men than women, but this trend fades in older age group. NAFLD is one of the most common causes of raised serum ALT levels and the latter is closely related to the presence of features of metabolic syndrome. NAFLD may contribute to metabolic syndrome in a similar way as visceral adiposity and can be an early predictor of metabolic disorders. NAFLD increases the risk of developing diabetes mellitus and is closely related to degree of glucose intolerance. A significant proportion of patients with NAFLD have impaired glucose tolerance or diabetes mellitus but with normal fasting blood glucose, highlighting the importance of oral glucose tolerance test in NAFLD patients with normal fasting blood glucose. Besides liver-related complications, NAFLD has been associated with cardiovascular complications, hyperuricemia, gout, chronic kidney disease, gallstone disease, colorectal adenomatous polyp, and polycystic ovarian syndrome. NAFLD seems to be related to host metabolic factors rather than viral factors and does not seem to affect severity of the liver disease in patients with chronic hepatitis B. On the other hand, hepatic steatosis may be related to both host metabolic and viral factors in patients with chronic hepatitis C and seems to adversely impact on the severity of liver disease and possibly response to antiviral therapy.
    Hepatology International 03/2012; 7(1). DOI:10.1007/s12072-012-9384-1 · 2.47 Impact Factor

Full-text (2 Sources)

Available from
May 31, 2014