Article

Interobserver variation in grading and staging of squamous cell carcinoma of the penis in relation to the clinical outcome

Department of Urology and Paediatric Urology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str. 7, D-24105 Kiel, Germany.
BJU International (Impact Factor: 3.13). 03/2009; 103(12):1660-5. DOI: 10.1111/j.1464-410X.2009.08362.x
Source: PubMed

ABSTRACT To examine interobserver variations in assessing grade and stage of penile squamous cell carcinoma (SCC).
We retrospectively reviewed the pathological features and clinical outcome in 75 patients with SCC of the penis, who were treated in participating urological centres between 1996 and 2005; the assessments of the local pathologists and the review pathologists were compared.
There was conformity in tumour grade in 67% and the assessment of tumour stage conformed in 84%; the combination assessment of both grade and stage conformed in 56%.
Accurate histological subtyping by the surgical pathologist demands standardized guidelines, in particular for histological grading, which is crucial for clinical treatment, but shows significant interobserver variation.

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    • "Our results are in agreement with a previous study evaluating penile tumors invading 5–10 mm, in which histological grade had more influence on prognosis than depth of tumor invasion (Velazquez et al. 2008). Given its importance and clinical implications histological grading should be carried out using uniform and comparable criteria, moreover considering that a significant interobserver variability has been reported for histological grading in penile carcinomas (Naumann et al. 2009). For patients included in this study, histological grading was carried out using strict (and previously validated) morphologic criteria (Chaux et al. 2009). "
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