Monitoring of cell cultures with LTCC microelectrode array

Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664, Warsaw, Poland.
Analytical and Bioanalytical Chemistry (Impact Factor: 3.44). 03/2009; 393(8):2029-38. DOI: 10.1007/s00216-009-2651-x
Source: PubMed


Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells. Noninvasive monitoring performed with the LTCC microelectrode array can be applied for future cell-engineering purposes.

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    • "Several applications of LTCC based microfluidic systems such as micro reactors for PCR applications [6], cell culture analysis systems [7], environmental [8] and biosensors [9] have been reported in literature recently. "
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    • "Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. For such purpose we proposed a miniaturized sensor array fabricated using LTCC technology [38]. The developed device was applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells [38]. "
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