Using Light to Reinstate Respiratory Plasticity
Duke University Medical Center, Department of Neurobiology, Box 3209, Bryan Res. Bldg, Research Dr., Durham, NC 27710, USA. Journal of Neurophysiology
(Impact Factor: 2.89).
03/2009; 101(4):1695-8. DOI: 10.1152/jn.00009.2009
Restoring normal function to damaged or diseased nervous tissue remains a major goal of both basic and clinical neuroscience research. Advances in genetic technologies now allow targeted control of neuronal activity in the mammalian nervous system, providing novel therapeutic avenues to repair or bypass faulty circuits. Here we review recent work published in the Journal of Neuroscience by Alilain et al., demonstrating the use of Channelrhodopsin-2 to restore breathing in rodent models of spinal cord injury.
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