Article

Magnetization transfer imaging reveals the brain deficit in patients with treatment-refractory depression

Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, PR China.
Journal of Affective Disorders (Impact Factor: 3.71). 03/2009; 117(3):157-61. DOI: 10.1016/j.jad.2009.01.003
Source: PubMed

ABSTRACT Studies on treatment resistant depression (TRD) using advanced magnetic resonance imaging techniques are very limited.
A group of 15 patients with clinically defined TRD and 15 matched healthy controls underwent magnetization transfer imaging (MTI) and T1-weighted (T1W) imaging. MTI data were processed and analyzed voxel-wised in SPM2. A voxel based morphometric (VBM) analysis was performed using T1W images.
Reduced magnetization transfer ratio was observed in the TRD group relative to normal controls in the anterior cingulate, insula, caudate tail and amygdala-parahippocampal areas. All these regions were identified within the right hemisphere. VBM revealed no morphological abnormalities in the TRD group compared to the control group. Negative correlations were found between MRI and clinical measures in the inferior temporal gyrus.
The cross-sectional design and small sample size.
The findings suggest that MTI is capable of identifying subtle brain abnormalities which underlie TRD and in general more sensitive than morphological measures.

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    • "Shan et al. have identified gray matter density or volume reductions in ACC, frontal, temporal, and parahippocampal areas [Shah et al., 2002]. In our previous study of TRD using magnetization transfer imaging [Zhang et al., 2009], reduced magnetization transfer ratio, indicative of abnormalities of brain tissue composition, was observed in the ACC, insular and parahippocampal areas. Other attempts to find metabolic or functional alterations in TRD have revealed increased blood flow in hippocampus-amygdala in TRD compared to both NDD and healthy controls [Hornig et al., 1997], and hypometabolism in cingulate, insula, frontal, and temporal areas in TRD, in association with different components of the severity and course of illness [Kimbrell et al., 2002]. "
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    • "ten Patienten und verglichen sie mit einer gesunden Vergleichs - gruppe . Dabei stellten sie fest , dass die depressiven Studienteilnehmer im Gegensatz zu den gesunden Probanden in mehreren Gehirnstrukturen einen pathologisch niedrigeren Wert der Magnetisierungstransfer - Ratio hatten – alle diese Regionen befanden sich in der rechten Hemisphäre ( Zhang et al . , 2009"
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