Article

Detox agents do not affect the pharmacokinetics of methamphetamine in the rat.

Doping Control Center, Korea Institute of Science and Technology, PO Box 131, Chungryang, Seoul, Republic of Korea.
Forensic science international (impact factor: 2.1). 03/2009; 186(1-3):e21-4. DOI:10.1016/j.forsciint.2009.01.007 pp.e21-4
Source: PubMed

ABSTRACT Recently, 'detox' agents have been popularly used as forms of diets or nutritional supplements. Especially, several cases have been reported that these detox agents have been used to mask drug tests among drug abusers. In the present study, capsule and drink types of detox agents were evaluated for their ability to alter the elimination of methamphetamine (MA) in rats. For this study, MA and its major metabolite, amphetamine (AP) in urine samples were determined using LC-tandem mass spectrometry after administration of the detox agents to MA-treated rats. As a result, significant differences were not shown between control and detox-dosed groups in the amounts of MA and AP excreted into urine as well as the volume of excreted urine. This result suggests that the detox agents tested may not affect the metabolism or elimination of MA and further might have minimal effect on narcotics detection in the urine samples of drug abusers.

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Keywords

'detox' agents
 
amounts
 
amphetamine
 
capsule
 
detox agents
 
diets
 
drink types
 
drug abusers
 
LC-tandem mass spectrometry
 
MA
 
MA-treated rats
 
major metabolite
 
mask drug tests
 
methamphetamine
 
narcotics detection
 
rats