Antibiotics for Uncomplicated Severe Malnutrition
New England Journal of Medicine (Impact Factor: 55.87). 06/2013; 368(25):2435-7. DOI: 10.1056/NEJMc1304407#SA3
To the Editor: Trehan et al. (Jan. 31 issue)(1) found that amoxicillin or cefdinir improved recovery from severe malnutrition among children in Malawi. The hypothesized reasons for their effectiveness include an underlying immunodeficiency related to malnutrition.(1),(2) However, although a major cause of immunodeficiency in Malawi is the human immunodeficiency virus (HIV), 68% of enrolled children were not tested for HIV; among those tested, 22% had HIV infection. Children known to be infected with HIV had the highest risk of treatment failure or death. Malnutrition is a well-known condition in children with HIV disease; outpatient therapeutic programs are important venues . . .
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