Article

Serum titers of IgG antibodies against tetanus and diphtheria toxoids and risk of multiple sclerosis.

Department of Nutrition, Harvard School of Public Health, Boston, MA, 02115, USA.
Journal of neuroimmunology (impact factor: 2.84). 03/2009; 208(1-2):141-2. DOI:10.1016/j.jneuroim.2009.01.006
Source: PubMed

ABSTRACT We conducted a prospective nested case-control study among military service members to investigate whether antibodies against tetanus or diphtheria predict multiple sclerosis (MS) risk. Paired T-tests were used to compare means of anti-tetanus and diphtheria toxoids among 56 MS cases and 112 matched controls. Conditional logistic regression was used to estimate odds ratios (OR). There were no differences between the mean serum IgG antibodies against tetanus (p-value 0.28) or diphtheria (p-value 0.45) in the baseline samples. The OR of MS associated with 1 standard deviation difference in antibody titers was 0.76 (95% CI: 0.48-1.21) for tetanus (SD=4.71) and 1.03 (0.73-1.45) for diphtheria (SD=0.87). Results of this study suggest serum IgG antibodies against tetanus or diphtheria are not predictors of MS risk.

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Keywords

1 standard deviation difference
 
56 MS cases
 
anti-tetanus
 
antibody titers
 
baseline samples
 
Conditional logistic regression
 
differences
 
diphtheria toxoids
 
estimate odds ratios
 
mean serum IgG antibodies
 
military service members
 
MS risk
 
multiple sclerosis
 
OR
 
Paired T-tests
 
prospective nested case-control study
 

J Massa