Article

P-gp transporter and its role in neurodegenerative diseases.

Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Pisa, Via Bonanno 6, I-56126 Pisa, Italy.
Current topics in medicinal chemistry (impact factor: 4.47). 02/2009; 9(2):209-17. pp.209-17
Source: PubMed

ABSTRACT This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) and Creutzfeldt-Jakob's (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy. For each pathological state, the direct and/or indirect involvement of P-glycoprotein (P-gp) efflux transport is underlined. On this basis, P-gp still represents an innovative target which can offer new tools for the development of more effective and preventive therapeutic strategies for neurodegenerative disorders. For each of them, therefore, a possible use of drugs affecting P-gp transport activity has been suggested.

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    International Journal of Molecular Sciences 01/2012; 13(6):6924-43. · 2.60 Impact Factor
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Keywords

ALS
 
Alzheimer's
 
amyotrophic lateral sclerosis
 
CJD
 
HD
 
indirect involvement
 
innovative target
 
P-gp
 
P-gp transport activity
 
pathological state
 
PD
 
possible use
 
preventive therapeutic strategies
 
recent insights